A PKPD interaction between Momordica charantia and oral hypoglycemic drug –dapagliflozin in STZ induced hyperglycemic rats
1 Department of Pharmacology, University College of Pharmaceutical Sciences, Satavahana University, Karimnagar, Telanagana, India.
2 Centre for pharmaceutical sciences, Jawaharlal Nehru Technological University, Hyderabad, Telanagana, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 24(03), 382–392.
Article DOI: 10.30574/gscbps.2023.24.3.0392
Publication history:
Received on 12 August 2023; revised on 26 September 2023; accepted on 28 September 2023
Abstract:
Traditional medications obtained from the medicated herbal plants are used by about maximum percentage of world population for different chronic disease condition. Diabetes (Hyperglycemia- high blood sugar level) is a very important metabolic disorder in different developed, developing countries including India. It providing to very serious complications on health of human beings, especially in the rural and subruralareas. Hence, the research studies required to be subjected to pharmacodynamic and pharmacokinetic studies in order to determine effect of Momordica charantia herb on the hyperglycaemic patients who are taking the therapy with synthetic drugs. This study was to discover the influence of Momordica charantia on the pharmacokinetics and pharmacodynamics of Dapagliflozinand in rats. Results have proved the negative (decrease) effect of Momordica charantia on pharmacokinetics but positive (increase) effect on pharmacodynamics of Dapagliflozin.
Keywords:
Momordica cherantia; Dapagliflozin Pharmacokinetics; Pharmacodynamic
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