A potential treatment with phytoestrogens: A literature review of experimental models on female rat’s reproductive health
1 Master of Midwifery Study Program, Faculty of Medicine Universitas Brawijaya, Malang, Indonesia.
2 Comprehensive Neonatal Emergency Obstetric Services (PONEK), Meuraxa Regional General Hospital, Banda Aceh, Indonesia.
3 Department of Midwifery, Faculty of Health Science Universitas Borneo Tarakan, Tarakan, Indonesia.
4 Vocational Faculty of Universitas Indonesia Maju, Jakarta, Indonesia.
5 Department of Clinical Parasitology Faculty of Medicine Universitas Brawijaya, Malang, Indonesia.
6 Department of Pharmacology Faculty of Medicine Universitas Brawijaya, Malang, Indonesia.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(01), 215–224.
Article DOI: 10.30574/gscbps.2024.28.1.0273
Publication history:
Received on 12 June 2024; revised on 21 July 2024; accepted on 23 July 2024
Abstract:
Introduction: Phytoestrogens are nonsteroidal substances produced from plants with biological properties such as estrogen. The two main types of phytoestrogens are flavonoids and non-flavonoids. Flavonoids, including isoflavones, are among the most estrogenic compounds, and due to their structural similarities, they can bind to estrogen receptors. Isoflavones have been found in various foods, including fruits, vegetables, sprouts, seeds, and oilseeds (including flaxseeds). This review focuses on plants phytoestrogens that contain flavonoids, isoflavones, daidzein, and genistein. In addition, isoflavones can also be considered endocrine disruptors with the possibility of negative effects on the state of health in certain parts of the population or environment. This literature review will include phytoestrogen-rich crop yields on the reproductive health of mice.
Method Systematic review: Literature searches are conducted on databases such as PubMed, ScienceDirect, Google Scholar, and Cochrane, with time limits. From 2014 to 2024, searches were carried out on this database, considering studies involving herbs, phytoestrogens, isoflavones, and genistein in ovariectomy rat’s model (OVX). The study found that plants rich in phytoestrogens can overcome post-ovariectomy complaints, increase estrogen levels, and increase normal cell proliferation. This herb is used as an effective alternative therapy in treating post-ovariectomy complaints.
Result: The search results found 2,401 studies on phytoestrogens and hypoestrogenics in the reproductive organs.
Conclusion: Phytoestrogens have active compounds that can improve the reproductive system after ovariectomy in female mice.
Keywords:
OVX; Isoflavones; Genistein; Phytoestrogen
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
