Preparation and characterization of quetiapine fumarate loaded transfersome as a novel drug delivery system
Department of Pharmaceutics, Centre for Pharmaceutical Sciences, JNTUH UCEST, JNTUH, Hyderabad, Telangana-500085, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 25(02), 372–386.
Article DOI: 10.30574/gscbps.2023.25.2.0463
Publication history:
Received on 21 September 2023; revised on 30 October 2023; accepted on 02 November 2023
Abstract:
Modern medicine delivery techniques like transdermal patches are vital for treating numerous disorders. With the aid of TDDS, first pass metabolism is prevented, which aids in achieving effective bioavailability. Drug molecules are also released into the systemic circulation at a controlled and predetermined rate. The objective of this study was creating matrix-type Quetiapine fumarate loaded transdermal patches with water bath method using different polymers like HPMC 5 cps, HPMC 15 cps, and Ethyl cellulose in different ratios. Polyethylene glycol-400, Dimethyl sulfoxide (DMSO) as a plasticizer and permeation enhancer, Solvents including methanol and chloroform in 1:1 ratio employed. FT-IR study indicated that pure drug and excipients are compatible with each other. The formulated patches are evaluated for thickness, weight variation, folding endurance, percentage moisture content, percentage moisture uptake, drug content and In vitro diffusion studies. A transfersomal formulation containing 25 mg of the drug and 10 mg of span 80 was concluded as the optimized formulation (F1) as it showed maximum drug entrapment (84.8%) and cumulative percent drug release (98.51%)
Keywords:
Transdermal drug delivery; Transferosomes; Quetipaine Fumarate; Stratum corneum
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
