Protective effect of Alchornea cordifilia leaf extract on carbon tetrachloride-induced liver damage in Wistar rats
1 Department of Biochemistry, Faculty of Science, University of Port-Harcourt, Rivers State, Nigeria.
2 Department of Pharmacology, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Port-Harcourt, Rivers State, Nigeria.
3 Department of Biomedical Technology, School of Science Laboratory Technology, University of Port-Harcourt, Rivers State, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(03), 190–195.
Article DOI: 10.30574/gscbps.2022.19.3.0235
Publication history:
Received on 11 May 2022; revised on 17 June 2022; accepted on 19 June 2022
Abstract:
The effect of aqueous extract of the leaves of Alchornea cordifolia on Carbon tetrachloride (CCl4)-induced liver damage was investigated in experimental rats. Treatment of separate groups of rats with 100mg/kg, 150mg/kg and 200mg/kg aqueous leaf extracts of Alchornea cordifolia for 2 weeks after establishment of CCl4 induced liver damage, resulted in significantly (P<0.05) less hepatotoxicity when compared to the CCl4-induced group, as measured by serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. The effect of extract was statistically significant (P<0.05) and was dose dependent. Histopathological study also showed significant reduction and even reversal of liver damage in the rats. The results of this study show that aqueous leaf extract of Alchornea cordifolia has a potent anti-hepatotoxic action against CCl4 induced liver damage in rats.
Keywords:
Alchornea cordifolia; Liver Damage; Carbon Tetrachloride (CCL4); Antioxidants; Phytochemicals
Full text article in PDF:
Copyright information:
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
