Qualitative phytochemical screening and in vitro thrombolytic activity of Capparis decidua Edgew. Fruit
1 Department of Botany, Government Meera Girls’ College, Udaipur-313001, Rajasthan, India.
2 Department of Medicine, Pacific Medical College & Hospitals, Udaipur-313001, Rajasthan, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(03), 160–167.
Article DOI: 10.30574/gscbps.2022.19.3.0232
Publication history:
Received on 10 May 2022; revised on 13 June 2022; accepted on 15 June 2022
Abstract:
Abnormal thrombosis plays an important role in development of ischemic heart disease and stroke. Synthetic thrombolytic agents are effective but possess some adverse effects. Therefore, the need for development of comparatively safer anti-thrombotic drugs from natural resources such as plants arises. Capparis decidua Edgew. (Family – Capparaceae) is a densely branched, xerophytic shrub and grows abundantly in arid and semiarid regions. Its fruits are major ingredient of the popular ‘Panchkuta’ vegetable of Rajasthan and also used to prepare pickle. Caper fruits are recommended for treatment of several diseases in traditional medicine including cardiac ailments and shown antioxidant and hypolipidemic potential in scientific studies and therefore, fruits of C. decidua were evaluated for their in vitro thrombolytic potential for the first time. Preliminary qualitative phytochemical screening of fruits of C. decidua; purchased from local market of Udaipur has shown the presence of flavonoids, terpenoids, phenol, phlobatanin, amino acids and carbohydrates and absence of saponin, tannins, steroids and cardiac glycosides. A significant percent clot lysis activity of 23.16±1.26 and 32.39±2.10 was exhibited by methanolic extracts (ME-I and ME-II) of fruits of C. decidua respectively as compared to the positive control streptokinase and negative control as distilled water. However, characterization of bioactive anti-thrombotic molecules as well as large scale, clinical studies is warranted to establish in vivo thrombolytic efficacy of its fruits. Thrombolytic potential of Caper berries as observed in the present study could be useful to recommend its consumption as a dietary health supplement in order to prevent from thrombotic cardiovascular diseases.
Keywords:
Cardiovascular Diseases; Clot Lysis; Platelet Aggregation; Stachydrine; Streptokinase
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