A review: Alcoholic liver disease pathophysiology, current molecular and clinical perspectives
1 Department of Pharmacy, Shraddha Institute of Pharmacy, Washim, Maharashtra, India.
2 Department of Quality Assurance, Shraddha Institute of Pharmacy, Washim, Maharashtra, India.
3 Department of Pharmacology, Shraddha Institute of Pharmacy, Washim, Maharashtra, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2023, 25(02), 014–024.
Article DOI: 10.30574/gscbps.2023.25.2.0424
Publication history:
Received on 06 September 2023; revised on 17 October 2023; accepted on 19 October 2023
Abstract:
Alcohol-related liver damage (ALD) is a term used for a variety of liver conditions comprising cirrhosis, fibrosis, and steatohepatitis with chronic inflammation that is predominantly brought on by heavy alcohol consumption. ALD is currently regarded as one of the most common causes of liver disease-related mortality on a global scale. The majority of cirrhosis in the liver cases seen in district general hospitals in the UK are caused by alcohol, which is a key factor in the Western world. Alcoholic cirrhosis, acute alcoholic hepatitis, and alcoholic fatty liver (steatosis) are the three most widely recognized types of alcoholic liver disease. According to the National Institute on Alcohol Abuse and Alcoholism's the most recent surveillance report, liver cirrhosis was among the top twelve causes of death in the country, contributing to a total of 14,477 deaths in the year 2014.This page speaks about the various types of alcoholic liver damage (ALD), with a focus on cirrhosis because it is the type of liver diseases that is most frequently linked to alcohol misuse and has the most studies investigating it. Epidemiological studies have assessed the incidence of ALD and the factors who frequently cause the condition. Although excessive alcohol use is the main cause of ALD, gender and cultural variations also have a significant role in the prevalence of liver disease. Since the 1970s, cirrhosis-related mortality rates have decreased in the United States and certain other countries as well. This dip may have been caused by a variety of variables, including increasing enrollment in alcohol rehab facilities and in Alcoholics Anonymous, drops in alcohol consumption, and more
Keywords:
Alcohol liver disease; Treatment; Translation medicine; Hepatic metabolism
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
