A review on cubosome: The novel drug delivery system
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, India.
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2018, 05(01), 076–081.
Article DOI: 10.30574/gscbps.2018.5.1.0089
Publication history:
Received on 21 August 2018; revised on 28 September 2018; accepted on 05 October 2018
Abstract:
Cubosomes are nanoparticles in structure which is mainly made of certain amphiphilic lipids in definite proportion, known as bicontinuous cubic phase liquid crystals. Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. They perform solid like rheology with unique properties of practical interest. They are thermodynamically stable and they have carvenous (honeycomb) structures which are tightly packed twisted into three dimensional bilayers. This type of complex structure allows them to have greater drug loading ability. Cubosomes have ability to encapsulate the hydrophobic, hydrophilic, amphiphilic substances. Cubosomes can increase the solubility of poorly soluble drug. Cubosome dispersions are bioadhesive and biocompatible. Because of their properties, cubosome are versatile systems, administrable by different ways such as orally, percutaneously and parenterally. Cubosome structure by means of electron microscopy, light scattering, x-ray and NMR, nevertheless few researchers has been studying the potential of cubosome as delivery systems.
Keywords:
Cubosomes; Nanoparticles; Bicontinuous; Honeycomb
Full text article in PDF:
Copyright information:
Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
