A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole
1 Department of Pharmacy, Shraddha Institute of Pharmacy, Washim, Maharashtra, India.
2 Department of Quality Assurance, Shraddha Institute of Pharmacy, Washim, Maharashtra, India.
3 Department of Pharmacology ,Shraddha Institute of Pharmacy, Washim, Maharashtra, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2023, 25(02), 169–179.
Article DOI: 10.30574/gscbps.2023.25.2.0433
Publication history:
Received on 09 September 2023; revised on 21 October 2023; accepted on 24 October 2023
Abstract:
Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World Health Organisation, Mycobacterium tuberculosis is the most dangerous chronic disease that can spread. The spread of Mycobacterium tuberculosis resistance is a serious issue. The examined bacterial strains were only partially and ineffectively active. Mycobacterium tuberculosis (Mtb), the bacterium that causes human tuberculosis (TB), is more common in multidrug-resistant strains, which is one of the main factors driving the development of new drugs to treat this variety of diseases. They have also been subjected to a traditional method of testing for their antibacterial and antifungal qualities. According to the outcomes of the activities, compounds exhibited moderate to good antibacterial and antifungal activity.
Keywords:
Mycobacterium tuberculosis; Benzothiazole; Antitubercular activity; Synthesis; Tuberculosis
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
