The role of matrix tablet in controlled release drug delivery system
1 Department of Pharmaceutics, Dr. Rajendra Gode College of Pharmacy, University Mardi Road, Amravati 444602, Maharashtra, India.
2 Department of Pharmaceutical Chemistry, Dr. Rajendra Gode College of Pharmacy, University Mardi Road, Amravati 444602, Maharashtra, India.
3 Department of Pharmacognosy, Dr. Rajendra Gode College of Pharmacy, University Mardi Road, Amravati 444602, Maharashtra, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2023, 23(01), 220–225.
Article DOI: 10.30574/gscbps.2023.23.1.0157
Publication history:
Received on 05 March 2023; revised on 18 April 2023; accepted on 21 April 2023
Abstract:
The purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. Matrix system was the earliest oral extended-release platform for medicinal use. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they offer better patient compliance, maintain uniform drug levels, reduce dose and side effects, and increase safety margin for high potency drugs. Hydrophilic polymer matrix systems are widely used for designing oral controlled drug delivery dosage forms because of their flexibility to provide a desirable drug release profile, cost effectiveness, and broad regulatory acceptance. However, the use of hydrophilic matrix alone for extending drug release for highly water-soluble drugs is restricted due to rapid diffusion of the dissolved drug through the hydrophilic gel network. For such drugs it becomes essential to include hydrophobic polymers in the matrix system. This leads to the conclusion that matrix tablets seem to be most promising when developing an oral controlled release formulation.
Keywords:
Controlled release; Hydrophilic matrix; Hydrophobic matrix; Matrix tablets; Polymers
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
