RP-HPLC method for simultaneous determination of escitalopram oxalate and flupentixol HCl in tablet dosage form
1 IBSS’s Dr. Rajendra Gode Institute of Pharmacy, Amravati-444 602, MS, India.
2 IBSS’s Dr. Rajendra Gode College of Pharmacy, Amravati-444 602, MS, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 14(01), 169-174.
Article DOI: 10.30574/gscbps.2021.14.1.0004
Publication history:
Received on 03 January 2021; revised on 10 January 2021; accepted on 12 January 2021
Abstract:
RP-HPLC method was developed for simultaneous determination of escitalopram oxalate (ESC) and flupentixol HCl (FLU) in tablet dosage form. Mobile phase consisting of mixture of acetonitrile and potassium phosphate buffer (pH 7.0 with 0.1% triethylamine) in the ratio 60: 40 at flow rate of 1ml/min using C18 Grace (250mmX 4.6mm) column at 231 nm. The retention time of ESC with FLU was found to be 2.96 min and 6.98 min, respectively. The linearity range for ESC with FLU observed was 5-25 µg/ml and 10-50 µg/ml, respectively. Method was validated as per ICH guidelines. Validation parameters studied were linearity and range, recovery study, precision, LOD, LOQ and robustness. Statistical data obtained was found to satisfactorily.
Keywords:
RP-HPLC; Escitalopram oxalate; Flupentixol HCl; Validation
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