Synthesis of 3-(substitutedthiocarbamide)-aniline derivatives from di-tert-butyl dicarbonate (BoC) protected 3-chloroaniline
1 Department of Chemistry, Govt. Vidarbha Institute of Science and Humanity, Amaravati, India.
2 Research Centre and Department of Chemistry, Padmashri Vikhe Patil College, Pravaranagar, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(03), 046–052.
Article DOI: 10.30574/gscbps.2024.28.3.0313
Publication history:
Received on 18 July 2024; revised on 30 August 2024; accepted on 02 September 2024
Abstract:
Synthesis of substituted thiocarbamide derivatives is important in the fields of medicinal, agricultural, chemical, and pharmaceutical. Thiocarbamides are commonly utilized as starting materials for several organic synthetic processes and have been studied in search for easy and effective methods of chemical synthesis. In the existing research work, 3-chloroaniline was protected by a di-tert-butyl dicarbonate (BoC) protecting agent. Substituted thiocarbamide derivatives were synthesized using condensation of various substituted thioureas with amino group-protected 3-chloroaniline. The structures of all compounds of 3(substitutedthiocarbamido)-aniline were characterized by 1H-NMR, 13C-NMR, FT-IR, LCMS and CHNS elemental analysis.
Keywords:
3-chloroaniline; Di-tert-butyldicarbonate; Thiocarbamide derivatives; Protecting agent
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