Synthesis and antibacterial activity of new 2-Thiosubstituted-3-Nitro Imidazo [1,2-a] pyridine derivatives
1 Laboratory of Constitution and Reaction of Matter, UFR Sciences of the Structures of Matter and Technology, Félix Houphouët-Boigny University, Abidjan, Ivory Coast, 22 BP 582 Abidjan 22.
2 Agrovalorisation Laboratory, Biochemistry-Microbiology Department, Jean Lorougnon Guede University, Daloa, Ivory Coast, BP 150 Daloa.
3 UFR of Biological Sciences, Department of Mathematics-Physics-Chemistry, Peleforo GON COULIBALY University, Korhogo, Ivory Coast, BP 1328 Korhogo.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 20(03), 160–166.
Article DOI: 10.30574/gscbps.2022.20.3.0352
Publication history:
Received on 07 August 2022; revised on 09 September 2022; accepted on 11 September 2022
Abstract:
To explore the antibacterial activity, a series of new 2-thioalkyl-3-nitroimidazo[1,2-a]pyridine derivatives (5a-k) were synthesized and characterized by 1H, 13C Nuclear Magnetic Resonance (NMR), and High-Resolution Mass Spectrometry (HRMS) analyses. These compounds were obtained by interaction of 2-(3-nitroimidazo[1,2-a]pyridin-2-yl)isothiouronium chloride salt 3 with functionalized alkyl chloride or bromide 4 in the presence of base. The synthesized compounds were evaluated in vitro on Gram-positive bacteria (Staphylococcus aureus ATCC 29213) and two others Gram-negative bacteria (Pseudomonas aeruginosa ATCC 27853 and Pseudomonas aeruginosa 933 C/21) by solid-state diffusion and liquid microdilution methods. None of the compounds showed any antibacterial activity on the bacteria tested.
Keywords:
Antibacterial Activity; Imidazo[1,2-a]pyridine; Functionalized Halides; Analysis; Staphylococcus aureus; Pseudomonas aeruginosa
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