Synthesis, characterization and anti-microbial activities of mixed ligand complexes of sulphamethoxazole-urea with cobalt (II) and zinc (II) ions in water-methanol medium
Department of Chemistry, Ekiti State University, PMB 5363, Ado-Ekiti, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(02), 215–224.
Article DOI: 10.30574/gscbps.2022.19.2.0149
Publication history:
Received on 12 April 2022; revised on 16 May 2022; accepted on 20 May 2022
Abstract:
Novel mixed ligand metal complexes of Zinc (II) and Cobalt (II) were respectively synthesized with sulphamethoxazole-urea in a water-methanol medium by refluxing method and characterized gravimetrically (using Mohr’s method for chloride and sulfur determination); the purity of the complexes through melting point determination; the functional groups present by infrared spectroscopy. The results predicted the coordination of the metals to the ligand through the amide group and oxygen atom of the sulphamethoxazole-urea bidentate. Solubility tests revealed that metal complexes were soluble in dimethyl sulphoxide acetone and ethanol. The metal complexes synthesized were also screened for their activities against some bacteria (Xanthomonas sp, E. coli, B. aureus, P. syrugiae, Staphylococcus sp., Bacillus aureus, and P. aureus) and some fungi (S. rolfsil, C. indimutiaum, C. capsicia) using Agar Disc diffusion principle. The metal complexes of sulphamethoxazole (SMX) and mixed ligands show little sign of bacteria inhibition but are more effective on fungi. The results indicate that the mixed ligand metal complexes were more biologically active than the free ligand. The better biological activity resulted in the MLC of Zn.
Keywords:
Cobalt (II); Zinc (II); Sulphamethoxazole-Urea; Spectroscopic Studies and Bioactivity Tests
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