Synthesis, characterization and in vitro antimicrobial activity of cyclic imide: Isoindoline-1, 3-dione derivatives
1Department of Chemistry, Saurashtra University, Rajkot-360005 (Gujarat), India.
2Department of Biosciences Saurashtra University, Rajkot-360005 (Gujarat), India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 10(01), 046-058.
Article DOI: 10.30574/gscbps.2020.10.1.0243
Publication history:
Received on 17 December 2019; revised on 11 January 2020; accepted on 13 January 2020
Abstract:
A series of new cyclic imide: isoindoline-1, 3-dione derivatives were synthesized by condensation of 2-hydrazinyl-2-oxo-N-phenylacetamide and phthalic anhydride. The characterization of synthesized compounds was done by IR, 1H NMR, 13C NMR and mass spectroscopy. All these synthesized compounds were tested for in vitro antimicrobial against various bacterial and fungal strains in N, N-dimethyl formamide and Dimethyl sulfoxide. It is observed that almost all the compounds showed moderate antimicrobial activity and N, N-dimethyl formamide is better solvent than dimethyl sulfoxide.
Keywords:
Cyclic imide; Isoindoline-1; 3-dione derivatives; N, N-dimethyl formamide; Dimethyl sulfoxide; Gram positive bacteria; Gram negative bacteria; Fungal strains
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
