Utilization of cell proliferation markers to diagnose cystic jaw pathologies
Oral Pathology Department, Faculty of Dentistry, Mansoura University, Egypt.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 16(03), 129–144.
Article DOI: 10.30574/gscbps.2021.16.3.0274
Publication history:
Received on 12 August 2021; revised on 16 September 2021; accepted on 18 September 2021
Abstract:
Markers of cell proliferation are widely used as diagnostic and prognostic tools. Coincident estimation of these markers increases the precise evaluation of the proliferative status of different tissues and can also be helpful in determining progression, aggressiveness and prognosis of the lesions. The current study investigated the expression of PCNA and MCM3 cell proliferation markers in 40 formalin fixed paraffin embedded tissue blocks of odontogenic keratocyst (OKC) and unicystic ameloblastoma (UA) cases using immunohistochemistry method. Markers` expression based on the intensity, percentage of positively stained cells and localization of reaction through the cyst lining epithelium was separately analyzed for each marker using Chi square test, the results of which were significant for the two markers (P < 0.05). Both markers revealed statistically significant differences between OKC and UA cases regarding markers expression intensity, positivity score and localization of reaction through the epithelium. Mural UA histologic variant was significantly different than luminal and intraluminal variants. The correlation coefficient between the two markers was found to be 0.86.
Keywords:
Odontogenic keratocyst (OKC); Unicystic ameloblastoma (UA); PCNA; MCM3; Cell proliferation markers
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Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
