UV spectrophotometric method for estimation of zileuton in pharmaceutical formulation
1Department of Pharmaceutical Analysis, Srikrupa Institute of Pharmaceutical Sciences, Siddipet-502 277 (TS).
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 13(01), 212-219.
Article DOI: 10.30574/gscbps.2020.13.1.0338
Publication history:
Received on 08 October 2020; revised on 16 October 2020; accepted on 20 October 2020
Abstract:
A simple, rapid, sensitive and accurate UV-spectrophotometric method has been developed for the estimation of zileuton in pharmaceutical formulation. The method was developed by using 0.1 N Sodium hydroxide as a solvent and absorbance was measured at 230 nm. The drug exhibited the linearity in the concentration range of 1-6 μg/ml with correlation coefficient of 0.9993. The % recovery of the drug was found to be 98.62 % - 100.5 %. The method was validated as per ICH guidelines. The proposed methods are economical and sensitive for the estimation of zileuton in bulk and tablet dosage form.
Keywords:
Zileuton; 0.1 N NaOH; UV-spectrophotometric method; ICH guidelines
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
