In vitro antioxidant capacity and in vivo anti-ulcer and analgesic potentials of dichloromethane fraction of stem barks from Boswelli dalzielii Hutch
1 Laboratory of Food Biochemistry, Enzymology, Biotechnology and Bioinformatic, University of Ouagadougou, 03 P.O.Box: 848, Ouagadougou 03, Burkina Faso.
2 Training and Research Unit in Applied and Technological Sciences, University of Dedougou, Burkina Faso.
3 Laboratory of Animal Physiology, UFR Bioscience, University of Felix Houphouet Boigny of Abidjan, 22 P.O. Box 582, Abidjan 22, Ivory Cost.
4 Laboratory of Animal Physiology, Electrophysiology and Pharmacology, Faculty of Sciences, University of Science and Technology of Masuku, Franceville, Gabon.
Research Article
GSC Biological and Pharmaceutical Sciences, 2018, 04(03), 007–017
Article DOI: 10.30574/gscbps.2018.4.3.0025
Publication history:
Received on 24 March 2018; revised on 08 August 2018; accepted on 14 August 2018
Abstract:
The present study was conducted to study the in vitro antioxidant, antiulcer and analgesic activities of dichloromethane fraction (DCMF) of stem barks from Boswelli dalzielii Hutch using different models in rats and mice. The antioxidant activity has been evaluated using β-carotene-linoleic acid system and lipid peroxidation and which showed antioxidant capacities. Antiulcer activity of dichloromethane fraction (DCMF) of stem barks from Boswelli dalzielii Hutch was studied in rats by administration of ethanol-induced method and by pyloric ligation method. The analgesic activity of dichloromethane fraction (DCMF) of stem barks from Boswelli dalzielii Hutch (Burseraceae) was tested using the model of acetic acid induced writhing in mice. The present study exhibit maximum radical scavenging activity and has positive effects in a dose dependent manner against ulcer induced by pyloric ligation-induced ulcers and cytoprotective model and analgesic activity using the model of acetic acid induced writhing in mice. The obtained results allow justifying the traditional uses of Boswelli dalzielii Hutch. This present study has clearly supported the utilization of Boswelli dalzielii Hutch in Burkina Faso traditional medicine.
Keywords:
Dichloromethane fraction; Stem barks; Boswelli dalzielii Hutch; Biological activities
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Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.
