Triazole fungicides induce hepatic lesions and metabolic disorders in rats
Ibn Zohr University, Faculty of Science, Laboratory of Cell Biology and Molecular Genetics, Agadir, Morocco.
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 10(02), 040-047.
Article DOI: 10.30574/gscbps.2020.10.2.0002
Publication history:
Received on 07 January 2020; revised on 15 January 2020; accepted on 20 January 2020
Abstract:
Pesticides are chemicals used in the treatment of agricultural products to increase production to meet growing consumer’s demand. Several studies have shown the toxic effects of these substances in humans as endocrine disrupters. The objective of our study is to highlight the toxic effects of hexaconazole in rats; a fungicide widely used in agriculture in Morocco. 16 rats received 100 mg/kg/day of hexaconazole orally via diet for 12 weeks. Biochemical analyses of the blood of treated animals showed a significant increase in creatinine, bilirubin, ASAT, ALAT and LDH levels, which would indicate toxicity in different organs. Also, a histological study of the liver was carried out. Microscopic observations showed several liver damages, such as centrilobular vein congestion, necrosis, immune cells infiltration, cholestasis, microvesicular and macrovesicular steatosis. These biochemical and histological results show that exposure to hexaconazole can cause liver and kidney damage. This pesticide would present an actual or potential danger to the consumer’s health.
Keywords:
Triazole; Hexaconazole; Toxicity; Hepatic lesions; Metabolic disorders; Rat
Full text article in PDF:
Copyright information:
Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
