Dietary protection by Tapinanthus globiferus (Mistletoe) leaf extract against prontosil-induced clastogenicity in mice in vivo
Department of Science Technology, Federal Polytechnic, Ado-Ekiti, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 10(03), 160-163.
Article DOI: 10.30574/gscbps.2020.10.3.0067
Publication history:
Received on 15 March 2020; revised on 25 March 2020; accepted on 28 March 20
Abstract:
Mistotoe (Tapinanthus globiferus) as freshly prepared leaf extract was administered at variable concentration (25, 50 and 100 mg/kg) per body weight as dietary supplement to laboratory albino mice via oral gavage for two weeks consecutively. The mice were also simultaneously administered 1.5 mg/kg pesticide precursor (Prontosil). 24 hours after the last day, the mice were sacrificed and chromosome preparations were made from the bone marrow cells. The end-points studied were polychromatic erythrocytes and damage cells. The results indicated that the clastogenicity in the mice fed with Tapinanthus globiferus leaf extract reduced significantly (P<0.05) compared to those fed with prontosil only. The marked reduction of clastogenicity by the extract may be attributed to the interaction with polyphenolic and phytochemical components of the extract.
Keywords:
Tapinanthus globiferus; Polychromatic erythrocytes; Prontosil; Clastogenicity.
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
