Relationship between vitamin D deficiency and premature atherosclerosis in an adolescents with type 1 DM through inflammatory IFN-γ
1 Master program of Biomedical Sciences Faculty of Medicine, Universitas Brawijaya, Malang 65145 Indonesia.
2 Pediatric department, Saiful Anwar General Hospital Malang 65112 Indonesia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 11(01), 055-068.
Article DOI: 10.30574/gscbps.2020.11.1.0032
Publication history:
Received on 06 February 2020; revised on 04 April 2020; accepted on 06 April 2020
Abstract:
Vitamin D deficiency has been related to increased risk of myocardial infarction, stroke. Type 1 DM patients have a higher risk of atherosclerosis, which is the leading cause of death in most patients, and IFN-γ is a pro inflammatory cytokine, and type 1 DM is a chronic inflammation. In our study, we try to detect the premature atherosclerosis in adolescents with type 1 DM who have vitamin D deficiency through inflammatory IFN-γ.
The study is a case control with 31 diabetic children aged 6 to 18 years as a case group, and control group 35 healthy children aged 10-18 years. We analysis the vitamin D, IFN- and ,HbA1c, and using Doppler US for cIMT of common carotid artery(CCA), and flow mediated dilation index(FMD%) of the brachial artery. And analysis the data through SPSS version16.0.
Type 1 DM group have higher levels of IFN-γ (p-0.005) and cIMT (p-0.01.) and both were significant, while the correlation effect of vitamin D deficiency and IFN-γ on both cIMT and FMD% were (p-0.294) and (p-0.270) (p-0.794)and (p-0.894) respectively and both insignificant, and correlation effect of HbA1c on cIMT was significant with (p-0.002), and correlation effect of HbA1c on FMD% was insignificant with (p-0.222).
We concluded that there is significantly higher of IFN-γ in type 1 DM, also a significant correlation effect of HbA1c on cIMT, and no relationship between vitamin D deficiency and premature atherosclerosis in an adolescents with type 1 DM through inflammatory IFN-γ.
Keywords:
Vitamin D deficiency; Type 1 DM; cIMT; FMD%
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