Improvement of performance of anti-cancer (dacarbazine) drug sensor utilizing tetraphenylborate anion
1 Chemistry Department, Al-Azhar University, Gaza, Palestine.
2 Chemistry Department, The Islamic University of Gaza, Gaza, Palestine.
3 Chemistry Department, College of Sciences, Al-Aqsa University, Gaza, Palestine
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 11(03), 092-103.
Article DOI: 10.30574/gscbps.2020.11.3.0163
Publication history:
Received on 04 June 2020; revised on 16 June 2020; accepted on 18 June 2020
Abstract:
A sensor for dacarbazine, an anticancer drug denoted DAC, is presented. A dacarbazine-modified carbon paste electrode was fabricated and improved by incorporation of sodium tetraphenylborate as an additive. Dacarbazine–phosphotungstate, a salt of dacarbazine abbreviated DAC-PT, was used in a carbon paste electrode as an ion-pair. Incorporation of sodium tetraphenylborate abbreviated STPB as an additive distinctly improved the slope from 43.7±0.3 to 55.6±0.3 mV per decade of DAC ion. The present electrode exhibits linearly over a wide concentration range from 1.80 × 10-6 to 1.0 × 10-2 M with a notably small detection limit of 8.9 × 10-7 M in a significantly fast response time (~ 5 s). These measurements are independent of the pH of the test solution in the pH range 3.2 to 9.5. The present sensor has distinct selectivity toward the drug ion over other common inorganic ions, sugars, amino acids, and drugs. This sensor was satisfactorily used as an indicator in potentiometric titrations and determination of dacarbazine in pharmaceutical preparations and urine samples.
Keywords:
Carbon paste electrodes; Dacarbazine; Anticancer drug; Potentiometry; Ion selective electrode
Full text article in PDF:
Copyright information:
Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
