Assessment of lipid peroxidation, antioxidant enzyme superoxide dismutase, glutathione and serum homocysteine level in patients with polycystic ovary syndrome in Sudan Khartoum state
1 Department of Clinical Chemistry, Alfalah Medical Polyclinic,Taif, Saudi Arabia.
2 Associate professor in clinical chemistry University of Science and Technology, Sudan.
3 Medical Laboratories Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE.
4 Department of Immunohematology, Albakkari Polyclinic, Almadinah Almunawarah, Saudi Arabia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 12(03), 196-203.
Article DOI: 10.30574/gscbps.2020.12.3.0300
Publication history:
Received on 17 September 2020; revised on 27 September 2020; accepted on 28 September 2020
Abstract:
Polycystic ovary syndrome (PCOS) is a common health problem that affects teenage girls and young women. PCOS is associated with a wide spectrum of complications in various parts of health, including reproductive, metabolic and psychological features. Analytical case control study was conducted to Assessment of Lipid peroxidation, antioxidant enzyme Super oxide dismutase, Glutathione and Serum Homocysteine level in Patients with (PCOS) in Khartoum State. A total of three hundred individuals were enrolled in this study, and classified into two groups, two hundred patients with (PCOS) as test group and hundred healthy individuals as control group, the samples were used to measure Homocysteine, Glutathione, Lipid peroxidation and superoxide dismutase level in the serum of participant with increased body mass index in study group and normal body mass index. The results were expressed as (mean ± SD).The mean ± standard deviation of the total glutathione was found mean 1174.5±271.5 and the reduced glutathione was (801.30 ±132.2), and for superoxide dismutase mean ± standard deviation (225.2, ± 57.8) in study group while in control group found 195.5, ± 25.6 respectively, Homocysteine mean ± standard deviation (14.9, ± 2.1) for test group and (12.1, ± 2.5) for control group. Lipid peroxidation mean ± standard deviation was found 3.4± 1.1 for test group and control group (2.4 ± 0.7) respectively. The present study has conculcated that mean of serum homocysteine, glutathione, lipid peroxide and superoxidase concentrations were increased in women with (PCOS), could be a dilemma for many women of reproductive ages irrespective of their reproductive disorders.
Keywords:
Polycystic ovary syndrome (PCOS); Lipid peroxidation; Antioxidant enzyme Superoxide dismutase
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