Development and evaluation of Pharmacosome formulations of Mefenamic acid
Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 16(03), 229–234.
Article DOI: 10.30574/gscbps.2021.16.3.0286
Publication history:
Received on 19 August 2021; revised on 27 September 2021; accepted on 29 September 2021
Abstract:
Patience who suffered from menstrual pain disease is generally prescribed the non-steroidal anti-inflammatory drug (NSAIDs). Monorrhagia or another blood disorder & some gynecological disorder, which impairs body function and acts as an economic burden. Due to respective use of ACE by oral route, it may cause GI complication such as bleeding, pain, perforation, abdominal pain, and swelling. To decrease the side effect of ACE, it is given by topical route in promotes the safety & efficacy of the ACE. The Mefenamic Acid pharmacosomes were prepared by the hand shaking method technique and evaluated by various methods such as in-vitro release study, % yield, drug entrapment efficiency, pH of the prepared formulation. The prepared system was also characterized by FTIR spectrophotometer to identify the drug-excipients interaction. The maximum entrapment efficiency of pharmacosomes was found to be 90%. The main aim of this study was to develop and characterized a vesicular drug carrier system for topical delivery of Mefenamic Acid to overcome the problem related with oral route.
Keywords:
Pharmacosomes; Mefenamic Acid; Topical delivery; Monorrhagia; Gynecological disorder.
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