Inhibition of prostate cancer by plant extracts used in the treatment of malaria in Burkina Faso
1 University of Nazi BONI, Training and Research unit in Sciences and Technology (UFR-ST), Department of Biochemistry and Microbiology, University of Nazi BONI, 01 BP 1091 Bobo-Dioulasso 01, Burkina Faso.
2 University Joseph Ki-Zerbo, Life and Earth Sciences Training and Research Unit (UFR-SVT), Laboratory of Biochemistry and Applied Chemistry (LA.BIO. C. A), 09 BP 848 Ouagadougou 09, Burkina Faso.
3 Laboratory for Research and Education in Animal Health and Biotechnology (LARESBA), University of Nazi BONI, 01 BP 1091 Bobo-Dioulasso 01, Burkina Faso.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(03), 100–108.
Article DOI: 10.30574/gscbps.2022.19.3.0209
Publication history:
Received on 25 April 2022; revised on 31 May 2022; accepted on 02 June 2022
Abstract:
Background and Objectives: Medicinal plants constitute the major source of malaria treatment in a different region of Burkina Faso, the present study was carried out to determine the potentially anti-malaria plants of the region of Bobo Dioulasso and to assess preliminary investigations on the possible pharmacological applications others than anti-malaria properties assessed by traditional health practitioners.
Materials and Methods: Open-ended and structured interviews were used during the ethnobotanical survey. Total phenolics and flavonoids content were estimated using spectrophotometric methods. Antioxidant potential was evaluated using anti-radical and reduction methods while the crystal violet staining technique was used for the determination of extracts cytotoxicity on 22RV1 prostate cancer cells.
Results: Ethnobotanical survey highlighted five plants from different families as the most used against malaria. Their extracts have shown a significant potential for trapping radicals by the 2,2'-azino-bis (3-éthylbenzothiazoline-6-sulphonique acid) (ABTS●+) method. The methanolic extract of T. macroptera has the highest content of phenolic and flavonoids compounds with respectively 59.94±0.15 mg EAG/100 mg of extract and 5.35±0.05 EQ/100 mg of extract. Methanolic extracts concentration of different plants tested that inhibit 50% of the proliferation of cancer cells 22RV1 proliferation were ranged between 48.34 to 359.1 μg/mL. E. africana was the most active 48.34 μg/mL on tested cell strain.
Conclusion: Phytochemical composition and antioxidant potential may justify the use of tested plants in the treatment of malaria. Antiradical potential and reduction capacities of tested samples may explain their toxicity 22RV1 prostate cancer cells.
Keywords:
Ethnobotanical Survey; Malaria; Polyphenols; Antioxidant; Cytotoxicity; Prostate Cancer Cells
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