Proteins in the kinetochore generate forces to drive chromosomes movement
1 Department of Medical Basic Science, College of Nursing, University of Thi-Qar- Iraq.
2 Marshes Research Center, University of Thi-Qar- Iraq.
3 Al Karama Teaching hospital, Wassit Health Office, Iraq.
Review Article
GSC Biological and Pharmaceutical Sciences, 2022, 20(02), 046–051.
Article DOI: 10.30574/gscbps.2022.20.2.0313
Publication history:
Received on 26 June 2022; revised on 31 July 2022; accepted on 02 August 2022
Abstract:
To accomplish the precise segregation of chromosomes, the kinetochore must be form incentive interaction with motor proteins. Any error happens in chromosome segregation led to aneuploidy that consider as main factor to cause the cancers and many birth defects. Kinetochore is a proteinous complex structure consist of a hundred of proteins. It’s performed many functions such as it connects movement of chromosomes to microtubule, it acts as observer for chromosomes biorentation, beside the main role in chromosomes segregation. In this review we described the proteins content of kinetochore and the important role of these proteins in generating forces to drive the movement of chromosomes, also we clarified some experiments that used to identify these proteins and support their functions.
Keywords:
Kinetochore; Chromosomes; Aneuploidy; KMN; FRAP
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
