A case report on drug rash with Eosinophiilia and systemic symptoms (DRESS) syndrome
1 Department of Pharmacy Practice, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, 391760, India.
2 Assistant Professor, Department of Pharmacy Practice, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, 391760, India.
3 Professor and Principal, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, 391760, India
Case Study
GSC Biological and Pharmaceutical Sciences, 2023, 22(01), 336–341.
Article DOI: 10.30574/gscbps.2023.22.1.0038
Publication history:
Received on 08 December 2022; revised on 24 January 2023; accepted on 26 January 2023
Abstract:
Background: DRESS syndrome is a distinctive, severe, and atypical drug reaction includes drug rash with eosinophilia and organ dysfunction symptoms, as well as hematological abnormalities. This disease is diagnosed using the Regis CAR (European Registry of Severe Cutaneous Adverse Reaction) scoring system.
Case presentation: A 25-year-old lady presented with complaints of skin lesion over whole body since 3 days along with multiple clear fluid filled blisters over face and chin and lesions in oral cavity, multiple ill-defined areas of erythema with multiple bullae over face and chin. She also had complained about was also having cough, breathlessness and chest pain.
Conclusion: DRESS syndrome is a severe hypersensitivity reaction caused by a reaction from drug, which in this case is found to be allopurinol. The treatment for the same is firstly the withdrawal of causative drug and using corticosteroids,in this patient dexamethasone was used.
Keywords:
DRESS; Eosinophilia; (HHV)-6 and -7; RegiSCAR; Allopurinol-induced
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