Investigating Corchorus olitorius hydrocolloid as a novel matrix former in sustained release delivery of ibuprofen tablet
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 24(01), 001–010.
Article DOI: 10.30574/gscbps.2023.24.1.0241
Publication history:
Received on 07 May 2023; revised on 27 June 2023; accepted on 29 June 2023
Abstract:
Corchorus olitorius gum in the native form has been researched for use in the food and pharmaceutical industry as a viscosity modifier and binder in immediate release oral tablets. This work sought to investigate the gum as matrix former in the sustained release delivery of Ibuprofen.
Corchorus gum was cold-extracted from the leafy plant part, dried and solid state characterization carried out. Tablets of ibuprofen were prepared using 20% of the gum as matrix former employing the wet granulation technique. Mechanical properties and the release kinetics, using dissolution studies, of the ibuprofen tablets were investigated. Obtained results were compared with those of tablets made with same concentration of a natural gum (Xanthan) and a synthetic one, Hydroxypropylmethylcellulose (HPMC) respectively.
Corchurus gum sustained the release of the drug for up to 8 hours, controlling a constant release at 20% in a sustained release formulation for from half hour to the four and a half hour duration. It also had a better swelling index than Xathan gum and hydroxypropylmethylcellulose (HPMC).Also tablets formulated had good physicomechanical properties that will make the native gum a good choice for use as a sustained release excipient
Keywords:
Corchorus gum; Ibuprofen; Sustained Release; Matrix Tablet; Release Kinetics
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
