Development and characterization of self micro emulsifying drug delivery system of rosavastatin
Department of Pharmaceutics, CMR College of pharmacy, Medchal, Hyderabad, Telangana, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2018, 03(01), 001–010.
Article DOI: 10.30574/gscbps.2018.3.1.0060
Publication history:
Received on 10 December 2017; revised on 11 February 2018; accepted on 24 February 2018
Abstract:
The present study was undertaken to enhance solubility and dissolution rate of rosuvastatin by formulating it as a self -micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using castor oil and sesame oil as oils, Tween 80 as surfactant and PEG 200 as co-surfactant. The prepared SMEDDS were further evaluated for drug content, thermodynamic stability and in vitro drug release. Among all the formulations the drug release for F2 formulation was 99.70% in 120 min. So it was considered as the optimized formulation. The selected optimized F2 formulation was characterized by drug excipient compatibility using FTIR spectroscopy, scanning electron microscopy and globule size. The stability studies indicate that the formulated SMEDDS was stable for 60 days.
Keywords:
Rosuvastatin; FTIR; SMEDDS; Tween80; PEG- 200; Ternary phase diagram; Globule size analysis
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Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.
