Phytochemical screening and evaluation of the antibacterial activity of extracts dichloromethane of total alkaloids from the leaves and roots of Guiera senegalensis (Combretaceae), a plant widely used in traditional Senegalese medicine
1 Department of Chemistry, Laboratory of Natural Products, Faculty of Science and Technology, Cheikh Anta Diop University of Dakar, Senegal.
2 Department of Chemistry, Organic chemistry and bioorganics laboratory, Faculty of Science and Technology, Cheikh Anta Diop University of Dakar, Senegal.
3 Waste water Treatment Laboratory, IFAN Cheikh Anta Diop, Dakar, Senegal.
4 Department of Pharmacy, Pharmacognosy and Botanic Laboratory, UCAD, Senegal.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 25(02), 293–304
Article DOI: 10.30574/gscbps.2023.25.2.0475
Publication history:
Received on 24 September 2023; revised on 16 November 2023; accepted on 19 November 2023
Abstract:
The present study involved extracting total alkaloids from the leaves and roots of Guiera senegalensis, a plant widely used in traditional Senegalese medicine. The results showed a low extraction rate.
A phytochemical screening of these alkaloid extracts was carried out and the results showed the presence of alkaloids and a total absence of other chemical groups, in particular polyphenols, flavonoids, catechic tannins and gall tannins.
Finally, antibacterial activity tests of alkaloid extracts from Guiera senegalensis leaves and roots were carried out on two pathogenic bacterial strains, namely "Gram +"Staphylococcus aureus and "Gram -" Escherichia coli. The results showed an antibacterial effect of the leaf extract on Staphylococcus aureus and Escherichia coli with a lower antibacterial power 4. The root alkaloid extract showed an antibacterial effect on Staphylococcus aureus with an even lower antibacterial potency 4. On the other hand, the root extract showed a bacteriostatic effect on Escherichia coli with an antibacterial potency greater than 4.
Keywords:
Guiera senegalensis; Alkaloids; Antibacterial activity; Phytochemical tests
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
