A recent update on gastro retentive drug delivery systems
School of Pharmacy LNCT University Kolar Road Bhopal, M.P(462042), India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 27(01), 125–144.
Article DOI: 10.30574/gscbps.2024.27.1.0119
Publication history:
Received on 28 February 2024; revised on 07 April 2024; accepted on 09 April 2024
Abstract:
Gastro retentive drug delivery systems (GRDDS) have garnered significant attention in recent years due to their potential to enhance therapeutic efficacy and patient compliance by prolonging gastric residence time and optimizing drug release kinetics. This review provides a comprehensive overview of the latest advancements in GRDDS, focusing on formulation strategies, design principles, and evaluation methodologies. Various approaches such as floating systems, mucoadhesive systems, expandable systems, and magnetic systems are discussed in detail, highlighting their mechanisms of action and applications in targeted drug delivery. Furthermore, recent innovations in materials science and formulation technologies have enabled the development of novel GRDDS with improved biocompatibility, stability, and controlled release profiles. The review also addresses challenges associated with GRDDS, including physiological variability, drug stability, and regulatory considerations, and proposes potential strategies to overcome these obstacles. Additionally, the clinical relevance of GRDDS in the treatment of various gastrointestinal disorders and their future prospects in personalized medicine and targeted therapy are explored. Overall, this review aims to provide valuable insights into the current state-of-the-art in GRDDS research and its implications for the advancement of drug delivery science.
Keywords:
Gastro retentive drug delivery system (GRDDS); Bio-adhesive; Mucoadhesive; Floating drug delivery system.
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
