Exploring lipids: A comprehensive review on their utilization in the formulation of liposomes, phytosomes, and ethosomes for advanced drug delivery systems"
1 Department of Quality Assurance, S. K. B. College of Pharmacy, Gada, Kamptee (MS) India.
2 Department of Quality Assurance Shraddha Institute of Pharmacy, Washim, (MS) India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(02), 099–115.
Article DOI: 10.30574/gscbps.2024.28.2.0244
Publication history:
Received on 25 June 2024; revised on 08 August 2024; accepted on 11 August 2024
Abstract:
This comprehensive review explores the diverse applications of lipids in the formulation of advanced drug delivery systems, specifically focusing on liposomes, phytosomes, and ethosomes. Lipids, crucial components in these formulations, play a pivotal role in enhancing drug solubility, stability, and bioavailability. The review systematically examines the latest advancements in lipid-based delivery systems, shedding light on their unique characteristics and applications. In the realm of liposomes, the study delves into various lipid compositions, highlighting their influence on liposomal structure and function. Additionally, the review explores the integration of phytosomes, which involve the complexation of drugs with plant-derived phospholipids, showcasing their potential to improve therapeutic efficacy. Ethosomes, lipid vesicles containing high concentrations of ethanol, are also extensively discussed, emphasizing their ability to enhance transdermal drug delivery. Critical analyses of recent research findings, including the impact of lipid selection on vesicle stability, drug release kinetics, and pharmacokinetics, are presented. The review further examines the challenges associated with lipid-based formulations, providing insights into potential avenues for future research and development. By synthesizing current knowledge, this review serves as a valuable resource for researchers, clinicians, and pharmaceutical scientists seeking a comprehensive understanding of the role of lipids in optimizing liposomal, phytosomal, and ethosomal drug delivery systems.
Keywords:
Lipid-based drug delivery; Liposomes; Phytosomes; Ethosomes; Advanced drug delivery systems.
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
