Encapsulation process of avobenzone in solid lipid microparticles by hot emulsification
1 Department of Pharmaceutics, Vidyabharti college of pharmacy, Amravati (MH), India
2 Department of quality assurance, Vidyabharti college of pharmacy, Amravati (MH), India
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(02), 199–207.
Article DOI: 10.30574/gscbps.2024.28.2.0284
Publication history:
Received on 25 June 2024; revised on 04 August 2024; accepted on 06 August 2024
Abstract:
Solid lipid microparticles (SLMs) containing significant amounts of the sunscreen ingredient butyl methoxydibenzoylmethane (avobenzone) were created in order to improve drug photostability. Numerous strategies, such as encapsulation, antioxidants, photostabilizers, and quenchers, have been employed to address the problems of photostability.A variety of methods have been used to find safe and efficient sunscreen ingredients in an effort to find the gold standard for photoprotection in medications that are photosensitive. Avobenzone was photostabilized via a solvent-free hot emulsification process using carnauba wax as the encapsulating medium.The encapsulation process produced a high efficiency since 96.41% of the avobenzone was successfully incorporated into the carrier system, resulting in a high encapsulation efficiency from the proposed procedure. The objective of study to provide drug delivery strategies applied for relatively high incorporation efficiency to reduce the sunscreen concentration needed, adequate microparticle size that precludes skin absorption and provides aesthetically pleasing qualities and controlled release of the sunscreen according to a biphasic pattern last over an in use relevant period of time which could be useful for photo unstable use of avobenzone.
Keywords:
Avobenzone; Solid Lipid Microparticles; Lipospheres; Photodegradation; Carnauba Wax; Encapsulation.
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
