The effect of oxidative stress on the kidneys
1 Department of Biology, College of Education for Pure Sciences, Kirkuk University, 52001 Kirkuk- Iraq.
2 Department of Chemistry, College of Dentistry, University of Kirkuk, 52001, Kirkuk, Iraq.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(02), 215–219.
Article DOI: 10.30574/gscbps.2024.28.2.0305
Publication history:
Received on 07 July 2024; revised on 21 August 2024; accepted on 23 August 2024
Abstract:
Free radicals have a strong ability to harm and destroy vital molecules in the body's cells, such as carbohydrates, lipids, proteins, and nucleic acids. The harm resulting from free radicals plays a major role in constantly increasing these radicals and in a series of reactions that lead to the destruction of vital molecules in the cell. Free radicals play a helpful role in destroying malignant tumor tissues by radiation, and they also have a role in demonstrating the action and effect of toxic substances and drugs. They also participate in various vital processes within the body's tissues as intermediate compounds, as biochemical stimulants work to stimulate enzymes through the association of the free radical with the protein part of the enzyme, thus stimulating the working mechanisms of that enzyme, such as the enzymes Catalase, Reductase , Peroxidase, and Oxidase.
Therefore, the current review dealt with a study on oxidative stress, including free radicals and antioxidants, and the effects of oxidative stress resulting from the use of drugs and antibiotics on some organs such as the liver, heart, aorta, lung and testicles in general, and the kidneys in detail by studying their effects on blood dynamics within the glomerulus and tubule cell toxicity and inflammation. And crystal nephropathy, rhabdomyolysis, vascular disorders, and nephron toxicity.
Keywords:
Free Radicals; Antioxidants; Drugs; Antibiotics; Kidneys
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
