Formulation and in vitro characterization of tapentadol HCL as immediate release tablets
Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2018, 04(03), 042–048
Article DOI: 10.30574/gscbps.2018.4.3.0072
Publication history:
Received on 27 July 2018; revised on 21 August 2018; accepted on 29 August 2018
Abstract:
The aim of the present study is to develop and evaluate the immediate release tablet of tapentadol by direct compression method. The superdisintegrant explotab, solutab and polyplasdoneXL were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F2 exhibits highest dissolution using explotab showed faster drug release 95.48 % over the period of 45 min while disintegration time of the tablet was showed 12 sec in comparison to other formulations of tapentadol.
Keywords:
Immediate release; Explotab; Solutab; Polyplasdone XL
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Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.
