Free radical scavenging activity of two edible vegetables from the Niger delta region of Nigeria
1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa state, Nigeria.
2 Department of Pharmaceutical chemistry, Faculty of Pharmacy, Madonna University, Elele, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2018, 05(02), 069–073
Article DOI: 10.30574/gscbps.2018.5.2.0092
Publication history:
Received on 23 August 2018; revised on 26 September 2018; accepted on 27 October 2018
Abstract:
Oxidative stress and diseases that have their aetiology and pathophysiology in reactive oxygen species can be prevented by medicinal plants and herbs. We undertook in this study, to investigate the free radical scavenging activity of dichloromethane (DCM) and ethanol (ETOH) extracts of Lasianthera africana and Gongronema latifolium in vitro using 2, 2, diphenyl-1-picrylhydrazine (DPPH). The leaves of both plants were obtained locally, washed, dried and pulverized using mechanical grinder. The powdered materials were defatted using n-hexane and subsequently extracted with DCM and thereafter with ETOH. The DPPH scavenging potentials of the extracts were then evaluated. The percentage inhibition of the DCM and ETOH extracts were; 46.2 and 80% respectively for L. africana and 37.2 and 82.6 respectively for G. latifolium. The standard substance (quercetin) produced 98.4 per cent inhibition at 1 mg/mL. The IC50 for the L. africana were; 2.017 and 3.256 mg/mL; DCM and ETOH extracts respectively. While that of G. latifolium were 1.495 and 1.116 mg/mL respectively for DCM and ETOH extracts. The standard substance produced IC50 of 0.55 mg/mL. The DPPH inhibitory activity was found to be prominent with the ETOH extracts of both plants. The result from this study validates the use of the leaves of both plants as supplements to improve health conditions and quality of life in general.
Keywords:
Gongronema latifolium; Lasianthera africana; Free radical; Phytochemical
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Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
