Spectrophotometric method for dissolution analysis of pioglitazone from capsules
1 Department of Chemistry, B. N. N. College, Bhiwandi, Thane, India.
2 Inventia Healthcare Pvt. Ltd., Thane, India.
3 Department of Chemistry, Ramnarain Ruia College, Mumbai, India.
Short Communication
GSC Biological and Pharmaceutical Sciences, 2018, 05(03), 025–027.
Article DOI: 10.30574/gscbps.2018.5.3.0131
Publication history:
Received on 05 November 2018; revised on 28 November 2018; accepted on 08 December 2018
Abstract:
Pioglitazone, an anti-diabetic molecule have been analyzed from a marketed capsule consisting of glimepiride and pioglitazone using spectrophotometric method. The method was developed at 270 nm using 0.1 N HCl as diluent. The method was found to be highly specific for pioglitazone in presence of glimepiride and other constituents of the capsule. The developed method is simple, precise, robust and stands validated as per ICH guidelines.
Keywords:
Pioglitazone; Anti-diabetic; Spectrophotometer; Glimepiride
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