Protective effects of vitamin E and grape seed oil against acute hepatorenal ivermectin toxicity in mice: biochemical and histopathological studies

El Maghraby Mai Mohsen 1, El Maghraby Nada Mosaad 1, Salama Ameera Ahmed 2, Abdlmonem Azza Shawky 2, Authman Eman Abdellatefe 2, Abdelmohsen Esraa Abdelraouf 2, Eltras Mohamed Abd-Elreheem 2, Barseem Omnia Nasr 2, Awad Shimaa Refat 2, Matter Ahmed Ashraf 2, Abo Sleam Ahmed Magdy 2, Elgozier Esraa Ahmed 2, Elnagar Mohamed Ali 2, El Bialy Badr El Said 3 and El Borai Nermeen Borai 3,* 

1 Undergraduate Student, Fifth Academic Year, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
2 Undergraduate Student, Fourth Academic Year, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
3 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 07(02), 087–094.
Article DOI: 10.30574/gscbps.2019.7.2.0079
Publication history: 
Received on 23 April 2019; revised on 14 May 2019; accepted on 16 May 2019
 
Abstract: 
Ivermectin (IVM), a broad spectrum anthelmintic drug, is considered a safe drug; however, there are few reports about its toxic effects in particularly at accidental overdose exposure. Therefore, the current study was designed to investigate the potential protective roles of vitamin E (Vit E) and grape seed oil (GSO) against the acute hepatorenal toxicity of IVM in mice. Mice were divided into four equal groups. Control vehicle group was administrated corn oil (0.2 ml/animal), IVM group was administrated IVM (6.5 mg/kg b.w.), Vit E+IVM group was administrated Vit E (200 mg/kg b.w.) plus IVM and GSO+IVM group was administrated GSO (0.2 ml/animal) plus IVM. All treatments were orally administrated daily for 3 weeks while IVM is administered as a single oral dose one day before the end of the experiment. The results revealed that IVM induced significant elevation in serum ALT and AST activities; urea and creatinine levels without any significant change in glucose level. No marked histopathological alterations were observed in hepatic tissue with several pathological alterations in the kidneys of IVM- intoxicated mice. However, pretreatment of mice with either Vit E or GSO ameliorated the IVM- induced biochemical and histopathological alterations. In conclusion, Vit E and GSO may provide a similar promising protective value against IVM acute hepatorenal intoxication.
Keywords: 
Ivermectin; Vitamine E; Grape seed oil; Hepatorenal toxicity; Histopathology
 
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Copyright information: 
Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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