Typhoid infection and its effect on liver function assessment among pregnant women in Owerri, Imo State, Nigeria
1 Department of Biological Sciences (Microbiology Programme), College of Basic and Applied Sciences, Rhema University Nigeria, P.M.B. 7021 Aba, Abia State, Nigeria.
2 Department of Microbiology, Abia State University Uturu, P.M.B. 2000 Uturu, Abia State, Nigeria.
3 Department of Internal Medicine, Abia State University Uturu. P.M.B. 2000 Uturu, Abia State, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 08(01), 105–113.
Article DOI: 10.30574/gscbps.2019.8.1.0096
Publication history:
Received on 29 May 2019; revised on 21 July 2019; accepted on 25 July 2019
Abstract:
Typhoid infection and its effect on liver function assessment among pregnant women were evaluated. Serum and blood samples were collected and processed for liver function assessment, widal test and microbiological identification of Salmonella typhi using standard methods. A total of ninety (90) patients were studied. Serum alanine transaminase (ALT) and Serum aspartate transaminase (AST) values for healthy pregnant women and pregnant women with typhoid infection had progressive value increase with increase in pregnancy time, except for the slight reduction in the third trimester with ALT. Mean values of healthy pregnant women and pregnant women with typhoid infection (iu/L) for ALT and AST were (8.93 ±1.07/ 9.95 ±0.19; 7.52 ±0.45/ 8.50 ±0.14) at first trimester, (10.62 ±1.19/11.64 ±0.05; 9.34 ±1.03/ 10.32 ±0.86) at second trimester and (9.81 ±0.16/ 10.83 ±0.76; 10.40 ±0.49/ 11.38 ±0.08) at third trimester, Conversely, total and conjugated bilirubin followed a different trend of retrogressive decrease with increase in pregnancy time. Total and conjugated bilirubin (mg/dL) mean values for healthy pregnant women and pregnant women with typhoid infection at first trimester were (0.56 ±0.87/ 0.69 ±0.09; 0.57 ±0.66/ 0.70 ±0.26), followed by second trimester (0.43 ±1.06/ 0.56 ±0.05; 0.48 ±0.77/ 0.61 ±0.03) and third trimester (0.32 ±0.57/ 0.45 ±0.11; 0.39 ±0.54/ 0.52 ±0.41). Values of LFT results among pregnant women with typhoid infection were higher than that of healthy pregnant women (p<0.05). Therefore, pregnancy alterations and infections could cause significant alterations in the results of LFT among pregnant women.
Keywords:
Typhoid infection; Liver function test (LFT); Physiological changes; Aspartate transaminase (AST); Alanine transaminase (ALT); Bilirubin
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
