Recent development in novel drug delivery systems for delivery of herbal drugs: An updates

Prajakta N.  Dongare; Anuja S.  Motule; Mahesh R.  Dubey; Manisha P.  More; Prerna A.  Patinge; Ravindra L.  Bakal; Jagdish V.  Manwar

doi:10.30574/gscarr.2021.8.2.0158

Authors

Prajakta N. Dongare IBSS’s Dr. Rajendra Gode Institute of Pharmacy, Mardi Road, Amravati-444 602, Maharashtra, India.
Anuja S. Motule IBSS’s Dr. Rajendra Gode Institute of Pharmacy, Mardi Road, Amravati-444 602, Maharashtra, India.
Mahesh R. Dubey IBSS’s Dr. Rajendra Gode Institute of Pharmacy, Mardi Road, Amravati-444 602, Maharashtra, India.
Manisha P. More IBSS’s Dr. Rajendra Gode Institute of Pharmacy, Mardi Road, Amravati-444 602, Maharashtra, India.
Prerna A. Patinge IBSS’s Dr. Rajendra Gode Institute of Pharmacy, Mardi Road, Amravati-444 602, Maharashtra, India.
Ravindra L. Bakal IBSS’s Dr. Rajendra Gode Institute of Pharmacy, Mardi Road, Amravati-444 602, Maharashtra, India.
Jagdish V. Manwar IBSS’s Dr. Rajendra Gode College of Pharmacy, Mardi Road, Amravati-444 602, Maharashtra, India.

DOI:

https://doi.org/10.30574/gscarr.2021.8.2.0158

Keywords:

Novel Drug Delivery, Herbal drug, Nanoparticles, Liposome, Phytosome

Abstract

In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs. Such systems are polymeric nanoparticles, nanocapsules, phytosomes, animations, microsphere, etc. The present article highlights the current condition of the development of novel herbal formulations and summarizes their type of active components, biological activity, and applications of novel formulations.

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References

Charman WN, Chan HK, Finnin BC. Drug delivery: a key factor in realizing the full therapeutic potential of drugs, Drug Dev Res. 1999; 46: 316-327.

Musthaba SM, et al. Status of novel drug delivery technology for phytotherapeutics. Expert Opin Drug Deliv. 2009; 6: 625-37.

Badukale NA, et al. Phytochemistry, pharmacology and botanical aspects of Madhuca indica: A review. Journal of Pharmacognosy and Phytochemistry. 2021; 10(2): 1280-1286.

Khadatkar SN, et al. Preparations and evaluation of microcapsules of capsaicin. International Journal of Chemical Sciences. 2007; 5(5): 2333-2341.

Sahare AY, et al. Hypericum perforatum: A Medicinal plant. Plant Archives. 2007; 7(2): 463-468.

Manmode R, et al. Effect of preparation method on antioxidant activity of ayurvedic formulation kumaryasava. J Homeop Ayurv Med. 2012; 1: 114.

Padgilwar S, et al. Traditional uses, phytochemistry and pharmacology of Oroxylum Indicum: A Review. International Journal of Pharmaceutical and Phytopharmacological Research. 2014; 3(6): 483-486.

Manwar J, et al. Isolation, biochemical and genetic characterizations of alcohol-producing yeasts from the flowers of Woodfordia fruticosa. J Young Pharm. 2013; 5(4): 191-194.

Wadekar AB, et al. Morphology, phytochemistry and pharmacological aspects of Carica papaya, an review. GSC Biological and Pharmaceutical Sciences. 2020; 14(03): 234-248.

Khadatkar SN, et al. In-vitro anthelmintic activity of root of Clitoria ternatea linn. 2008; 4(13): 148-150.

Sahare AY, et al. Antimicrobial activity of Pseudarthria viscida roots. Asian Journal of Microbiology Biotechnology & Environmental Sciences. 2008; 10(1): 135-136.

Gudalwar BR, et al. Allium sativum, a potential phytopharmacological source of natural medicine for better health. GSC Advanced Research and Reviews. 2021; 06(03): 220–232.

Malode GP, et al. Phytochemistry, pharmacology and botanical aspects of Murraya Koenigii in the search for molecules with bioactive potential - A review. GSC Advanced Research and Reviews. 2021; 06(03): 143–155.

Nikhare AM, et al. Morphological, Phytochemical and pharmacological aspects of Syzigium Cumini. International Journal of Medical, Pharmaceutical and Biological Sciences. 2021; 1(1): 1-11.

Bijewar AH, et al. Overture in development, properties and clinical aspects of biosurfactants: An review. International Journal of Medical, Pharmaceutical and Biological Sciences. 2021; 1(1): 1-12.

Parbat AY, et al. Ethnopharmacological review of traditional medicinal plants as immunomodulator. World Journal of Biology Pharmacy and Health Sciences. 2021; 06(02): 043–055.

Dongare PN, et al. An Overview on herbal cosmetics and cosmoceuticals.Int J Pharm Sci Rev Res. 2021; 68(1): 75-78.

Biju SS, Talegaonkar S, Khar RK, Vesicular system: an overview. Indian J Pharm Sci. 2006; 68(2): 141-153.

Sharma A, Sharma US. Liposomes in drug delivery: progress and limitations. Int J Pharm.1997; 154: 123-40.

Saraf AS. Applications of novel drug delivery system for herbal formulations. Fitoterapia. 2010; 81: 680-9.

Sharma G, Anabousi S, Ehrhardt C, Ravi Kumar MN. Liposomes as targeted drug delivery systems in the treatment of breast cancer. J Drug Target. 2006; 14: 301‑10.

Ajazuddin, Saraf S. Applications of novel drug delivery system for herbal formulations. Fitoterapia. Elsevier B.V.2010; 81(7): 680–9.

Chaturvedi M, Kumar M, Sinhal A, Saifi A. Recent development in novel drug delivery systems of herbal drugs. Int J Gr Phar. 2011; 5(2): 87-94.

Semalty A, Semalty M, Rawat MSM. The Phyto-phospholipid complexes- phytosomes: a potential therapeutic approach for herbal hepatoprotective drug delivery. Pcog rev. 2007; 1(2): 369-74.

Goyal A, Kumar S, Nagpal M, Singh I, Arora S. Potential of novel drug delivery systems for herbal drugs. Ind J Pharm Edu Res. 2011; 45(3): 225-35.

Mohanraj VJ, Chen Y. Nanoparticles: a review. Trop J Pharm Res. 2006; 5(1): 561-73.

Saraf AS. Applications of novel drug delivery system for herbal formulations. Fitoterapia. 2010; 81: 680-9.

Nagavarma BVN, Yadav HKS, Ayaz A, Vasudha LS, Shivakumar HG. Different techniques for preparation of polymeric nanoparticles- A review. Asian J Pharm Clin Res. 2012; 5(3): 16–23.

Tangri P, Khurana S. Niosomes: Formulation and evaluation. Int J Biopharm. 2011; 2(2): 47-53.

Gupta S, Singh RP, Lokwani P, Yadav S, Gupta SK. Vesicular system as targeted drug delivery system: an overview. Int J Pharm Tech. 2011; 3(2): 987-1021.

Shukla ND, Tiwari M. Proniosomal drug delivery systems - Clinical applications. Int J Res Pharm Biomed Sci. 2011; 2(3): 880-7.

Goyal C, Ahuja M, Sharma SK. Preparation and evaluation of anti-inflammatory activity of gugulipid-loaded proniosomal gel. Acta Pol Pharm Drug Res. 2011; 68(1): 147-50.

Rav GS, Dubey A, Hebbar, S. Development of maltodextrin based proniosomes derived niosomes of Ofloxacin. Int. J. Pharm. Sci. Res. 2019; 10(3): 1485-1490.

Madni A, et al. Enhancement of dissolution and skin permeability of pentazocine by proniosomes and niosomal gel. AAPS PharmSciTech. 2018; 19(4): 1544–1553.

Ahmad MZ, et al. Technology overview and drug delivery application of proniosome. Pharm. Dev. Technol. 2017; 22(3): 302–311.

Prasad NS, et al. Augmentation of dissolution profile of poorly soluble Olmesartan medoximil formulating into pronisomes. European JBPS. 2016; 3(2): 122-128.

Abdallah MH, Sabry SA, Hasan AA. Enhancing transdermal delivery of glimepiride via entrapment in proniosomal gel. J Young Pharm. 2016; 8(4): 335-340.

Cheriyan P, et al. Formulation and characterization of maltodextrin based proniosomes of cephalosporins. Pharm. Sci. 2015; 3(1): 62-74.

Asijia R, et al. Development of proniosomes gel as a drug carrier for transdermal delivery of acyclovir. J Drug Deliv Ther. 2014; 2(18): 41-51.

Soujanya CP, Ravi P. Development and in vivo evaluation of lovastatin loaded transdermal proniosomal gel by design of experiment. Int. J. Pharm. Sci. Drug Res. 2018; 10(4): 252-259.

Lather V, Sharma D, Pandita D. Proniosomal gel-mediated transdermal delivery of bromocriptine: in vitro and ex vivo evaluation. J Exp Nanosci. 2016; 11(13): 1044-1057.

Yuksel N, et al. In situ niosome forming maltodextrin proniosomes of candesartan cilexetil: In vitro and in vivo evaluations. Int. J. Biol. Macromol. 2016; 82: 453-63.

Jukanti R, et al. Provesicular drug delivery systems: An overview and appraisal. Arch. Appl. Sci. Res. 2010; 2(4): 135-146.

Ramkanth S, et al. Development, characterization & in vivo evaluation of proniosomal based transdermal delivery system of Atenolol. Future J. Pharm. Sci. 2018; 4(1): 80-87.

Benipal G. Design, development and evaluation of proniosomal gel of an antifungal drug- Ketoconazole. Int J Pharm Sci Rev Res. 2018; 31(2): 265-277.

Vyas SP, Khar RK. Niosomes targeted and controlled drug delivery. CBS Publishers and Distributors. 249-279.

Seetha Devi, et al. Formulation and evaluation of candesartan cilexetil transdermal proniosomal gel. J. Drug Deliv. Ther. 2014; 4(2): 90-98.

Chinga NL, Gupta M. Preparation and characterization of metformin proniosomal gel for treatment of diabetes mellitus. Asian J. Pharm. Sci. 2020; 15: 13–25.

AlsarraA, et al. Proniosomes as a drug carrier for transdermal delivery of ketorolac. Eur J Pharm and Biopharm. 2004; 105: 1-6.

Rajkumar J, et al. Recent update on proniosomal gel as topical drug delivery system. Asian J Pharm Clin Res. 2019; 12(1): 54-61.

Aswathi et al.A review on proniosomes- controlled drug delivery system.Indo Am. J. Pharm. Sci. 2018; 5(8): 7584-7589.

Upadhye et al. Proniosomes: A novel vesicular drug delivery system. Am. J. PharmTech Res. 2020; 10(2): 260–273.

Nimbalwar MG, Upadhye K, Dixit G. Fabrication and evaluation of ritonavir Proniosomal transdermal gel as a vesicular drug delivery system. Pharmacophore. 2016; 7(2): 82-95.

Sabhadinde AF, et al. Novel RP-HPLC method for simultaneous analysis of chlorthalidone and telmisartan from combined dosage form. Ijppr.Human. 2020; 20(1): 491-502.

Panchale WA, et al. RP-HPLC method for simultaneous determination of escitalopram oxalate and flupentixol HCl in tablet dosage form. GSC Biological and Pharmaceutical Sciences. 2021; 14(01): 169-174.

Nimbokar SW, et al. Development and validation of RP-HPLC method for determination of zonisamide from tablet formulation. World Journal of Pharmaceutical and Medical Research. 2021; 7(2): 196-200.

Panchale WA, et al. RP-HPLC method for simultaneous determination of metformin hydrochloride and linagliptine in pharmaceutical dosage form. World Journal of Pharmaceutical and Medical Research. 2021; 7(5): 234- 238.

Manwar JV, et al. Development of newer RP-HPLC method for simultaneous estimation of cefiximeand linezolide in bulk drugs and combined dosage form. International Journal of Pharmacy and Life Sciences. 2021; 12(1): 26-31.

Panchale WA, Gulhane CA, Manwar JV, Bakal RL. Simultaneous estimation of salbutamol sulphate and ambroxol HCl from their combined dosage form by UV-Vis spectroscopy using simultaneous equation method. GSC Biological and Pharmaceutical Sciences. 2020; 13(03): 127-134.

Bakal RL, et al. Spectrophotometric estimation of amitriptyline HCL and chlordiazepoxide in tablet dosage form. International Journal of Chemical Sciences. 2007; 5(1): 360–364.

Panchale WA, Bakal RL. First-order derivative spectrophotometric estimation of gemifloxacin mesylate and ambroxol HCl in tablet dosage form. GSC Biological and Pharmaceutical Sciences. 2021; 14(2): 029-036.

Gulhane CA, et al. Liquid chromatographic method for simultaneous estimation of thiocolchicoside and etoricoxib from tablet formulation. Asian Journal of Pharmaceutical Analysis. 2021; 11(2): 118-122.

Panchale WA, et al. Chromatographic analysis of famotidine, paracetamol and ibuprofen from tablet formulation. Research Journal of Pharmacy and Technology. 2019; 12: 231-263.

Manwar JV, et al. Application of simultaneous equation method for the determination of azithromycin and cefixime trihydrate in tablet formulation. Research Journal of Pharmacy and Technology. 2017; 10(1): 108-112.

Manwar JV, et al. Response surface based optimization of system variables for liquid chromatographic analysis of candesartan cilexetil. Journal of Taibah University for Science. 2017; 11: 159–172.

Manwar J, Mahadik K, Paradkar A, et al. Gas chromatography method for the determination of non-ethanol volatile compounds in herbal formulation. International Journal of Analytical and Bioanalytical Chemistry. 2013; 3(1): 12-17.

Panchale WA, et al. Concurrent analysis of ambroxol HCl and salbutamol sulphate from tablet formulation by RP-HPLC. GSC Biological and Pharmaceutical Sciences. 2020; 13(03): 197-202.

Manwar JV, et al. Experimental design approach for chromatographic determination of ketorolac tromethamine from bulk drug and tablet formulation. Global Journal of Pharmacy & Pharmaceutical Sciences. 2017; 3(2): 38-47.

Manmode RS, et al. Stability indicating HPLC method for simultaneous determination of methocarbamol and nimesulide from tablet matrix. Der Chemica Sinica.2011; 2(4): 81-85.

Bagade SB, et al. Simultaneous high performance thin layer chromatographic estimation of methocarbamol and nimesulide in combined dose tablet. Journal of Pharmaceutical Research. 2006; 5(4): 137-140.

Gulhane CA, et al. UV- Visible Spectrophotometric estimation of azithromycin and cefixime from tablet formulation by area under curve method. World Journal of Pharmaceutical Sciences. 2021; 9(6): 163-168.