Influence of osteoporosis on quality of life and current strategies for its management and treatment

Kanwal Ashiq; Khurrum  Rehman; Sana Ashiq; Ahlam Sundus

doi:10.30574/gscbps.2017.1.2.0051

Authors

Kanwal Ashiq University College of Pharmacy, University of the Punjab Lahore, Pakistan
Khurrum Rehman Lahore Pharmacy College, Lahore Medical and Dental College, Lahore Pakistan
Sana Ashiq Microbiology and Molecular Genetics Department, University of the Punjab Lahore, Pakistan
Ahlam Sundus Lahore Pharmacy College, Lahore Medical and Dental College, Lahore Pakistan

DOI:

https://doi.org/10.30574/gscbps.2017.1.2.0051

Keywords:

Osteoporosis, Quality of life, Socio-economic burden, Management, Treatment

Abstract

Osteoporosis is a silent disease which is more common among women and elderly people. Drastic increase in the incidents of osteoporotic related fractures is a major health concern these days. It negatively influences the quality of life and not only affects the physical, psychological and social activity of people but also increases the monetary burden, and is one of the major causes of morbidity and mortality. The patients who experience the osteoporotic fractures are often depressed due to chronic pain, restricted mobility, fear of fall, and dependence on others. Globally, the economical burden for treatment is too high. Poor implementation of guidelines regarding the diagnosis of disease and availability of the treatment also affects the patient’s quality of life. For better quality of life in patients with osteoporosis; awareness programs, prior diagnosis, accessibility to treatment and patient counseling are necessary. This review is the summarized data, which was taken from published work between 2005 and 2017. Aim of the current review is to highlight the impact of osteoporosis on patient’s quality of life and to evaluate the current trends in the management of such life devastating disease. It also focuses on diagnosis and treatment strategies available globally. The data generated in this review may be significant in developing policies regarding prevention of osteoporosis, its management and reduction in the cost burden of treatment.

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References

Lorentzon M and Cummings S. (2015). Osteoporosis: the evolution of a diagnosis. Journal of internal medicine, 277 (6), 650-661.

Raisz LG. (2005). Pathogenesis of osteoporosis: concepts, conflicts, and prospects. The Journal of clinical investigation, 115 (12), 3318-3325.

Emkey GR and Epstein S. (2014). Secondary osteoporosis: pathophysiology and diagnosis. Best practice and research Clinical endocrinology and metabolism, 28 (6), 911-935.

Kuru P, Akyüz G, Cerşit HP, Çelenlioğlu AE, Cumhur A, Biricik Ş, Kozan S, Gökşen A, Özdemir M and Lüleci E. (2014). Fracture history in osteoporosis: risk factors and its effect on quality of life. Balkan medical journal, 31 (4), 295.

Becker DJ, Kilgore ML and Morrisey MA. (2010). The societal burden of osteoporosis. Current rheumatology reports, 12 (3), 186-191.

Lips P and van Schoor NM. (2005). Qol in patients with osteoporosis.Osteoporosis international, 16 (5), 447-455.

Gauthier A, Kanis JA, Jiang Y, Martin M, Compston JE, Borgström F, Cooper C and McCloskey EV. (2011). Epidemiological burden of postmenopausal osteoporosis in the UK from 2010 to 2021: estimations from a disease model. Archives of osteoporosis, 6 (1-2), 179-188.

Lerner U. (2016). Bone remodeling in post-menopausal osteoporosis. Journal of dental research, 85(7), 584-595.

Tanaka Y, Nakayamada S and Okada Y. (2005). Osteoblasts and osteoclasts in bone remodeling and inflammation. Current Drug Targets-Inflammation and Allergy, 4 (3), 325-328.

Rachner TD, Khosla S and Hofbauer LC. (2011). New horizons in osteoporosis. Lancet, 377 (9773), 1276.

Sipos W, Pietschmann P, Rauner M, Kerschan-Schindl K and Patsch J. (2009). Pathophysiology of osteoporosis. WMW Wiener Medizinische Wochenschrift, 159 (9), 230-234.

Duque G and Troen BR. (2008). Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. Journal of the American Geriatrics Society, 56 (5), 935-941.

Kamel HK. (2006). Postmenopausal Osteoporosis. Journal of Managed Care Pharmacy, 12 (6 Supp A), S4-S9.

Dennison E, Mohamed MA and Cooper C. (2006). Epidemiology of osteoporosis.Rheumatic Disease Clinics, 32 (4), 617-629.

Pisani P, Renna MD, Conversano F, Casciaro E, Di Paola M, Quarta E, Muratore M and Casciaro S. (2016). Major osteoporotic fragility fractures: Risk factor updates and societal impact. World journal of orthopedics, 7 (3), 171.

Dhanwal DK, Dennison EM, Harvey NC and Cooper C. (2011). Epidemiology of hip fracture: worldwide geographic variation. Indian journal of orthopaedics, 45 (1), 15.

Harvey N, Dennison E and Cooper C. (2010). Osteoporosis: impact on health and economics. Nature Reviews Rheumatology, 6 (2), 99-105.

Hübscher M, Vogt L, Schmidt K, Fink M and Banzer W. (2010). Perceived pain, fear of falling and physical function in women with osteoporosis. Gait and posture, 32 (3), 383-385.

Hung WW, Egol KA, Zuckerman JD and Siu AL. (2012). Hip fracture management: tailoring care for the older patient. Journal of American Medical Association, 307 (20), 2185-2194.

Ishikawa Y, Miyakoshi N, Kasukawa Y, Hongo M and Shimada Y. (2009). Spinal curvature and postural balance in patients with osteoporosis. Osteoporosis international, 20 (12), 2049-2053.

Adachi JD, Adami S, Gehlbach S, Anderson FA, Boonen S, Chapurlat RD, Compston JE, Cooper C, Delmas P and Díez-Pérez A. (2010). Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women. In Mayo Clinic Proceedings, Elsevier, 85(9), 806-813.

Suzuki N, Ogikubo O and Hansson T. (2009). The prognosis for pain, disability, activities of daily living and quality of life after an acute osteoporotic vertebral body fracture: its relation to fracture level, type of fracture and grade of fracture deformation. European Spine Journal, 18 (1), 77-88.

Suzuki N, Ogikubo O and Hansson T. (2008). The course of the acute vertebral body fragility fracture: its effect on pain, disability and quality of life during 12 months. European Spine Journal, 17 (10), 1380-1390.

Smulders E, Van Lankveld W, Laan R, Duysens J and Weerdesteyn V. (2011). Does osteoporosis predispose falls? A study on obstacle avoidance and balance confidence. BMC musculoskeletal disorders, 12 (1), 1.

Silverman SL, Piziak VK, Chen P, Misurski DA and Wagman RB. (2005).Relationship of health related quality of life to prevalent and new or worsening back pain in postmenopausal women with osteoporosis. The Journal of rheumatology, 32 (12), 2405-2409.

Madureira MM, Ciconelli RM and Pereira RM. (2012). Quality of life measurements in patients with osteoporosis and fractures. Clinics, 67 (11), 1315-1320.

Erez HB, Weller A, Vaisman N and Kreitler S. (2012). The relationship of depression, anxiety and stress with low bone mineral density in post-menopausal women. Archives of osteoporosis, 7 (1-2), 247-255.

Bianchi ML, Orsini MR, Saraifoger S, Ortolani S, Radaelli G and Betti S. (2005). Quality of life in post-menopausal osteoporosis. Health and quality of life outcomes, 3 (1), 78.

Mezuk B, Eaton W and Golden S. (2008). Depression and osteoporosis: epidemiology and potential mediating pathways. Osteoporosis International, 19 (1), 1-12.

Abourazzak FE, Allali F, Rostom S, Hmamouchi I, Ichchou L, El Mansouri L, Bennani L, Khazzani H, Abouqal R and Hajjaj-Hassouni N. (2009). Factors influencing quality of life in Moroccan postmenopausal women with osteoporotic vertebral fracture assessed by ECOS 16 questionnaire. Health and quality of life outcomes, 7 (1), 23.

Borer KT. (2005). Physical activity in the prevention and amelioration of osteoporosis in women. Sports medicine, 35 (9), 779-830.

Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey E, Jönsson B and Kanis J. (2013). Osteoporosis in the European Union: medical management, epidemiology and economic burden. Archives of osteoporosis, 8 (1-2), 136.

Cosman F, De Beur S, LeBoff M, Lewiecki E, Tanner B, Randall S and Lindsay R. (2014). Clinician’s guide to prevention and treatment of osteoporosis. Osteoporosis International, 25 (10), 2359-2381.

Bouee S, Lafuma A, Fagnani F, Meunier P and Reginster J-Y. (2006). Estimation of direct unit costs associated with non-vertebral osteoporotic fractures in five European countries. Rheumatology International, 26 (12), 1063-1072.

Atik OS, Gunal I and Korkusuz F. (2006). Burden of osteoporosis. Clinical orthopaedics and related research, 443, 19-24.

King AB, Tosteson AN, Wong JB, Solomon DH, Burge RT and Dawson‐Hughes B. (2009). Interstate variation in the burden of fragility fractures. Journal of Bone and Mineral Research, 24 (4), 681-692.

Tosi LL and Kyle RF. (2005). Fragility fractures: the fall and decline of bone health. The Journal of Bone and Joint Surgery, Inc., 87(1), 1-2.

Hiligsmann M, Evers SM, Sedrine WB, Kanis JA, Ramaekers B, Reginster J-Y, Silverman S, Wyers CE and Boonen A. (2015). A systematic review of cost-effectiveness analyses of drugs for postmenopausal osteoporosis. Pharmacoeconomics, 33 (3), 205-224.

Lane NE. (2006). Epidemiology, etiology, and diagnosis of osteoporosis. American journal of obstetrics and gynecology, 194 (2), S3-S11.

Zone C and Guide S. (2017). Postmenopausal osteoporosis. Sign, 3531 (936).

Gehrig L, Lane J and O'connor MI. (2008). Osteoporosis: management and treatment strategies for orthopaedic surgeons. Journal of Bone and Joint Surgery, 90 (6), 1362-1374.

Delaney MF. (2006). Strategies for the prevention and treatment of osteoporosis during early postmenopause. American journal of obstetrics and gynecology, 194 (2), S12-S23.

Rachner TD, Khosla S and Hofbauer LC. (2011). Osteoporosis: now and the future. The Lancet, 377 (9773), 1276-1287.

Kammerlander C, Gosch M, Kammerlander-Knauer U, Luger TJ, Blauth M and Roth T. (2011). Long-term functional outcome in geriatric hip fracture patients. Archives of orthopaedic and trauma surgery, 131 (10), 1435-1444.

Harvey N, Dennison E and Cooper C. (2014). Osteoporosis: a lifecourse approach. Journal of Bone and Mineral Research, 29 (9), 1917-1925.

Lai PSM, Chua SS and Chan SP. (2013). Impact of pharmaceutical care on knowledge, quality of life and satisfaction of postmenopausal women with osteoporosis.International journal of clinical pharmacy, 35 (4), 629-637.

Elias M, Burden A and Cadarette S. (2011). The impact of pharmacist interventions on osteoporosis management: a systematic review. Osteoporosis international, 22 (10), 2587.

Lötters F, Lenoir-Wijnkoop I, Fardellone P, Rizzoli R, Rocher E and Poley M. (2013). Dairy foods and osteoporosis: an example of assessing the health-economic impact of food products. Osteoporosis international, 24 (1), 139-150.

Reginster J-Y and Burlet N. (2006). Osteoporosis: a still increasing prevalence. Bone, 38 (2), 4-9.

Melton LJ, Kanis JA and Johnell O. (2005). Potential impact of osteoporosis treatment on hip fracture trends. Journal of Bone and Mineral Research, 20 (6), 895-897.

Alexandraki KI, Syriou V, Ziakas PD, Apostolopoulos NV, Alexandrakis AI, Piperi C, Kavoulaki E, Myriokefalitakis I, Korres G and Diamanti-Kandarakis E. (2008). The knowledge of osteoporosis risk factors in a Greek female population. Maturitas, 59 (1), 38-45.