Formulation and evaluation of lovastatin oral disintegration thin films

Pragathi Pagilla; P Vishnu; Abbulu Konde

doi:10.30574/gscbps.2018.3.2.0061

Authors

Pragathi Pagilla Department of Pharmaceutics, CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad, India.
P Vishnu Department of Pharmaceutics, CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad, India.
Abbulu Konde Department of Pharmaceutics, CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad, India.

DOI:

https://doi.org/10.30574/gscbps.2018.3.2.0061

Keywords:

Croscarmellose sodium, Crospovidone, Lovastatin, Oral disintegrating thin films

Abstract

Lovastatin is a statin drug used to prevent and treat coronary heart disease and to treat high cholesterol. In the present study, oral disintegrating thin films (ODTs) of lovastatin were designed with a view to enhance patient compliance by solvent casting method. In the solvent casting method, Croscarmellose sodium (CCS) (2, 4 and 6 % w/w), Crospovidone (10 and 15% w/w) as superdisintegrants were used in different concentrations with Gelatin, Poly vinyl alcohol (PVA) as a film forming base for the formulation of oral disintegrating thin films of lovastatin. The prepared formulations of films were evaluated for film thickness measurement, folding endurance study, in-vitro disintegration time, in-vitro drug release pattern and drug content. FTIR spectroscopy used to study drug-polymers interaction. Among all formulations, the formulation (F8) prepared by 4% crospovidone show enhanced drug release (99.27%) and it showed good stability for period of three months. Conclusively, the present study documents the development of a commercially viable formula lovastatin ODTs with rapidity in reducing heart problems.

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