Development and evaluation of sustained release microparticles of atenolol of gastrointestinal delivery

Prakash Reddy Aduri; Uddandu Saheb Shaik; Maheswari Moodu; Suvarsha Gaddam; Monika Anga

doi:10.30574/gscbps.2018.3.2.0026

Authors

Prakash Reddy Aduri Dhanvanthari Institute of Pharmaceutical Sciences, Kothagudem, Telangana, India, 507120.
Uddandu Saheb Shaik Dhanvanthari Institute of Pharmaceutical Sciences, Kothagudem, Telangana, India, 507120.
Maheswari Moodu Dhanvanthari Institute of Pharmaceutical Sciences, Kothagudem, Telangana, India, 507120.
Suvarsha Gaddam Dhanvanthari Institute of Pharmaceutical Sciences, Kothagudem, Telangana, India, 507120.
Monika Anga Dhanvanthari Institute of Pharmaceutical Sciences, Kothagudem, Telangana, India, 507120.

DOI:

https://doi.org/10.30574/gscbps.2018.3.2.0026

Keywords:

Atenolol, Microparticles, Eudragit RL 100, Magnesium stearate

Abstract

The aim of the present study is to development and evaluation of sustained release micro particulates of atenolol prepared by solvent evaporation technique. In this method Eudragit RS-100 was dissolved in Acetone and suitable solvent was mixed well with the pure Atenolol drug with different ratios and filtered it. Add magnesium stearate and it was dispersed in solution by ultra sonification. This solution keep it on a side and take another fresh beaker contain 100 ml of liquid paraffin and add 20 ml of n-hexane. Both liquid paraffin and n-hexane stirred continuously by using mechanical stirrer. In this solution add previous ultra sonification solution in the form of drops with the help of syringe until acetone evaporated. By this process microparticles were formed and they dried at room temperature. The drug product percentage yield, drug entrapment efficiency, particles size parameters are in desired manner. The in-vitro drug release studies Shows that the percentage of drug release is in standard level. Among all formulations F3 and F5 formulations with drug, polymer was found to be satisfactory in terms of excellent micromeritic properties, percent yield (92.12%), Drug entrapment efficiency (77.79%), Percent buoyancy (80%) and highest in-vitro drug release of 85.60% in sustained manner over an extended period of time for 12 hrs.

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References

Lwise Donald. (2000). Hand book of pharmaceutical controlled release technology, New York, 271.

Agon P, Goethals P, Van Haver D and Kaufman JM. (1991). Permeability of the blood–brain barrier for atenolol studied by positron emission tomography. Journal of Pharmacy and Pharmacology, 43 (8), 597–600.

Lalitha K, Kiranjyothi R and Padma B. (2013). UV spectrophotometric method development and validation for the determination of atenolol and losartan potassium by q analysis. International Bulletin of Drug Research, 3(4), 54-62.

Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K and Dhawan. (2004). Chitosan microspheres as a potential carrier for drugs. International Journal of Pharmaceutics, 274, 1–33.

Mahmoud MA, Saleh Abd El-Rasoul, Sayed HA and Mohamed AI. (2011). Emulsification/internal gelation as a method for preparation of diclofenac sodium-sodium alginate microparticles. Saudi Pharmaceutical Journal, 21(1), 61-69.

Srivastava AK, Ridhurkar DN and Wadhwa S. (2005). Floating microspheres of Cimetidine: formulation, characterization and in vivo evaluation. Acta Pharmaceutica, 55(3), 277-285.

Reddy JRK, Gnanaprakash K, Badarinath AV and Chetty CMS. (2009). Formulation and evaluation of microparticles of metronidazole. Journal of Pharmaceutical Sciences and Research, 1, 131-136.

Murty SB, Wei Q, Thanoo BC and Deluca PP. (2004). In vivo release characteristics of octreotide acetate from experimental polymeric microsphere formulations using oil/water and oil/oil processes. AAPS PharmSciTech 5(3), 49.

Nayak BS, Nayak UK, Patro KB and Rout PK. (2008). Preparation and in vitro evaluation of lamivudine entrapped MOI microspheres for oral administration. Research Journal of Pharmacy and Technology, 1(4), 437-9.

Gohel MC and Amin AF. (1999). Studies in preparation of Diclofenac sodium microspheres by solvent evaporation technique using response surface analysis. Indian Journal of Pharmaceutical Sciences, 61(1), 48-53.

Umamaheswari RB, Jain S, Bhadra D and Jain NK. (2003). Floating microspheres bearing acetohydroxamic acid for the treatment of H. pylori. Journal of Pharmacy and Pharmacology, 55, 1607-13.