Formulation and in vitro characterization of tapentadol HCL as immediate release tablets

Kumar Paramasivam Suresh; Batlanki Priyanka; Vemula Sindhu; Patro Varanasi Jagannath; Kumar T Praveen; Sulthana Syed  Yasmin

doi:10.30574/gscbps.2018.4.3.0072

Authors

Kumar Paramasivam Suresh Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.
Batlanki Priyanka Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.
Vemula Sindhu Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.
Patro Varanasi Jagannath Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.
Kumar T Praveen Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.
Sulthana Syed Yasmin Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.

DOI:

https://doi.org/10.30574/gscbps.2018.4.3.0072

Keywords:

Immediate release, Explotab; Solutab, Polyplasdone XL

Abstract

The aim of the present study is to develop and evaluate the immediate release tablet of tapentadol by direct compression method. The superdisintegrant explotab, solutab and polyplasdoneXL were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F2 exhibits highest dissolution using explotab showed faster drug release 95.48 % over the period of 45 min while disintegration time of the tablet was showed 12 sec in comparison to other formulations of tapentadol.

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References

Jishan Ali Ahmed. (2015). A review on immediate release tablet dosage form. Human Journals, 2(3), 1-17.

Bindu T, Kumar P, Rao JR, Rao PN and Manasa M. (2014). Formulation and development of Sorafenib tosylate immediate release tablet. International Journal of Innovative Pharmaceutical Sciences and Research, 2(7), 1386-1401.

Bokshi B and Malakar A. (2012). Formulation and evaluation of Allylestrenol immediate release tablets. IJPSR, 3(6), 1679-83.

Jadhav SB, Mali AD, Rajeghadage SH and Bathe RS. (2014). Formulation and evaluation of immediate release tablets of Imipramine hydrochloride. Int. J. Biomed. Adv. Res, 5(11), 559-565.

Neha D, Kamini KM, Neeraj P, Manmohan S, Kamal V and Neeraj SN. (2017). Immediate release tablets: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 6(4), 595-611.

Jagdale SC, Patil SA and Kuchekar BS. (2012). Design, development and evaluation of floating tablets of tapentadol hydrochloride using chitosan. Asian Journal of Pharmaceutical and Clinical Research, 5(4), 163-168.

Vadivelu N, Timchenko A, Huang Y and Sinatra R. (2011). Tapentadol extended-release for treatment of chronic pain: a review. Journal of pain research, 4, 211.

Vilegave, K, Vidyasagar, G and Chandankar P. (2013). Preformulation studies of pharmaceutical new drug molecule and products: An Overview. Am. J. Pharm Health Res, 1(3), 1-20.

Vageesh NM, Sura RS, Rafian D and Govindamma U. (2017). Preparation and In vitro charactersation of fast disintigrating tablets of cimetidine. Innovat International Journal of Medical and Pharmaceutical Sciences, 2(4), 1-6.

Reddy DV and Rao DAS. (2014). Formulation and evaluation of extended release tablets of Tapentadol hydrochloride using hydrophilic-hydrophobic polymer combinations. J Pharma Res, 8(10), 1368-1374.

Teklu, L, Adugna E and Ashenef A. (2014). Quality evaluation of paracetamol tablets obtained from the common shops (kiosks) in Addis Ababa, Ethiopia. International journal of pharmaceutical sciences and research, 5(8), 3502.

Maheswarappa MK and Desai PD. (2014). Design and in-vitro evaluation of mouth dissolving tablets of olanzapine. Asian Journal of Pharmaceutics, 5(2).

Mohammad S, Mohammad S, Bijja S and Ashraf B. (2014). Evaluation of tablets by friability apparatus. International Journal of Research in Pharmacy and Chemistry, 4(4), 837-840.

Aher VS, Bhairav BA and Saudagar RB. (2016). Formulation evaluation and comparative study of zolmitriptan mouth dissolving tablet. Asian Journal of Pharmacy and Technology, 6(4), 207-216.

Son YJ and McConville JT. (2009). Development of a standardized dissolution test method for inhaled pharmaceutical formulations. International Journal of Pharmaceutics, 382(1-2), 15-22.