Anti-inflammatory activity Keelvayu nivarana churnam in carrageenan induced inflammatory rats

V. Elango; G. Vijayabaskar

doi:10.30574/gscbps.2018.5.1.0084

Authors

V. Elango Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu, S. India.
G. Vijayabaskar Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu, S. India.

DOI:

https://doi.org/10.30574/gscbps.2018.5.1.0084

Keywords:

Anti-inflammatory activity, Keelvayu nivarana churnam, Carrageenan, Indomethacin

Abstract

Anti-inflammatory activity of Keelvayu nivarana churnam in carrageenan induced inflammatory rats was evaluated. Keelvayu nivarana churnam at the doses of 10, 15 mg/kg and 25 mg/kg of body weight in experimental animals. Anti-inflammatory activity was evaluated by Carrageenan induced paw edema in rats. Indomethacin (3 mg/Kg body weight) was employed as standard drug. Animals were randomized into 4 group (n = 6). Control group receives vehicle only. Keelvayu nivarana churnam treated with high dose which produced significant inhibition of edema and pain. This study confirms Keelvayu nivarana churnam possesses significant anti-inflammatory efficacy.

Metrics

Metrics Loading ...

References

Sembulingam K and Prema Sembulingam, (2012). Essentials of Medical Physiology, 6th edition, Jay pee Brothers Medical Publishers (P) Ltd, 431-432.

Opie EL. (1962). On the relation of necrosis and inflammation to denaturation of proteins. The Journal of Experimental Medicine, 115(3), 597-608.

Umapathy E, Ndebia EJ, Meeme A, Adam B, Menziwa P, Nkeh-Chungag BN and Iputo JE. (2010). An experimental evaluation of Albuca setosa aqueous extract on membrane stabilization, protein denaturation and white blood cell migration during acute inflammation. Journal of Medicinal Plants Research, 4, 789-795.

American college of rheumatology NSAID; Treatment portal, https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/NSAIDs, last accessed on 08/05/2018

Morgan Chris. (2002). Medicine of the Gods : Basic Principles of Ayurvedic Medicine, Mandrake publication, Chapter 1, 97-98

Winter CA, Risley EA and Nuss GW, (1962 Dec). Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine, 111(3), 544–547.

Vane JR and Botting RM. (1995). New insights into the mode of action of anti-inflammatory drugs. Inflammation Research, 44(1), 1–10.

Hernández-Pérez M and Rabanal Gallego RM. (2002). Analgesic and antiinflammatory properties of Sideritis lotsyivar Mascaensis. Phytotherapy Research, 16(3), 264–266.

Christopher JM. (2003). Inflammation protocols. Humana Press Inc, 115-121

Thenmozhi V, Elango V and Sadique J. (1989) Anti-inflammatory activity of some Indian medicinal plants., Ancient Science of Life, 8(3&4), 258-261

Syed Ismail T, Gopalakrishnan S, Hazeena Begum V and Elango V. (1997). Anti-inflammatory activity of Salacia oblonga Wall. and Azima tetracantha Lam. Journal of Ethnopharmacology, 56(2), 145-152

Sadique J, Chandra T, Thenmozhi V and Elango V. (1987). Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation. Journal of Ethnopharmacology, 19(2), 201–212.