Spectrophotometric method for dissolution analysis of pioglitazone from capsules

Authors

  • Jain Kalpana Patankar- Department of Chemistry, B. N. N. College, Bhiwandi, Thane, India.
  • Parag Gadkari Inventia Healthcare Pvt. Ltd., Thane, India.
  • Pushkar Pradhan Department of Chemistry, Ramnarain Ruia College, Mumbai, India.

DOI:

https://doi.org/10.30574/gscbps.2018.5.3.0131

Keywords:

Pioglitazone, Anti-diabetic, Spectrophotometer, Glimepiride

Abstract

Pioglitazone, an anti-diabetic molecule have been analyzed from a marketed capsule consisting of glimepiride and pioglitazone using spectrophotometric method. The method was developed at 270 nm using 0.1 N HCl as diluent. The method was found to be highly specific for pioglitazone in presence of glimepiride and other constituents of the capsule. The developed method is simple, precise, robust and stands validated as per ICH guidelines.

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References

Guideline IHT. (2005). Validation of analytical procedures: text and methodology Q2 (R1). In International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH), Geneva, Switzerland, 11-12.

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Published

2018-12-30

How to Cite

Patankar-, J. K., Gadkari, . P., & Pradhan, P. (2018). Spectrophotometric method for dissolution analysis of pioglitazone from capsules. GSC Biological and Pharmaceutical Sciences, 5(3), 025–027. https://doi.org/10.30574/gscbps.2018.5.3.0131

Issue

Vol. 5 No. 3 (2018): December 2018

Section

Short Comunication

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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