Screening of aerial parts of the plant Clerodendrum paniculatum Linn for anti-anxiety activity

K Priyanka; IJ Kuppast; B Ramesh; SV Gururaj; HV Annegowda

doi:10.30574/gscbps.2019.8.1.0159

Authors

K Priyanka Department of Pharmacology, Adichunchanagiri University, Sri Adichunchanagiri College of Pharmacy, BG Nagar, Karnataka – India.
IJ Kuppast Department of Pharmacology, National College of Pharmacy, Shivamogga, Karnataka – India
B Ramesh Department of Pharmaceutical chemistry, Adichunchanagiri University, Sri Adichunchanagiri College of pharmacy, BG Nagar, Karnataka – India
SV Gururaj Department of Botany, Sri Sai PU College, Shivamogga, Karnataka – India
HV Annegowda Department of pharmacognosy, Adichunchanagiri University, Sri Adichunchanagiri College of pharmacy, BG Nagar, Karnataka – India.

DOI:

https://doi.org/10.30574/gscbps.2019.8.1.0159

Keywords:

Clerodendrum paniculatum Linn, Verbenacae, Anti-anxiety activity, Ethylacetate, Flavonoids, Diazepam

Abstract

The present study was undertaken to investigate and validate the traditional claims of Clerodendrum paniculatum Linn for its anti-anxiety activity. C. paniculatum linn belongs to Verbenacae family. Ethnomedical importance of various species of Clerodendrum genus has been reported in various indigenous systems of medicines and folk medicines. It is used as a medicine for the treatment of sore eyes, gonorrhoea, urinary tract infection and kidney problems. Till date there are no reports available regarding its pharmacological properties of hence, it is therefore worthwhile to study the unrevealed properties of this plant. The shade dried aerial parts of plant were extracted by extracted using ethyl acetate, petroleum ether and aqueous as a solvent. Obtained extracts were subjected for phytochemical screening and antianxiety activity was studied using elevated plus maze and light and dark models. Results of the phytochemical screening revealed the presence of flavonoids, tannins, glycosides, saponins, and terpenoid like compounds. In addition, among the extracts studied for anti-anxiety activity of ethyl acetate extract shown significant activity comparable with standard drug, diazepam. Petroleum ether and aqueous extracts shown least anti-anxiety activity in comparison with the standard.

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