An insight of non-steroidal anti-inflammatory drug mefenamic acid: A review

Rajat Srivastava; Manoj Kumar Mishra; Amit Kumar Patel; Abhishek Singh; Krishna Kushwaha

doi:10.30574/gscbps.2019.7.2.0066

Authors

Rajat Srivastava Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj, Uttar Pradesh, India-211012.
Manoj Kumar Mishra Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj, Uttar Pradesh, India-211012.
Amit Kumar Patel Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj, Uttar Pradesh, India-211012.
Abhishek Singh Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj, Uttar Pradesh, India-211012.
Krishna Kushwaha Lutawan Institute of Pharmacy, Sakara Jaitpura, Ghazipur, Uttar Pradesh, India-233001.

DOI:

https://doi.org/10.30574/gscbps.2019.7.2.0066

Keywords:

Anti-inflammatory drugs, Mefenamic acid, Rheumatoid arthritis, Dosage formulations

Abstract

This review focuses on the design, synthesis and pharmacological effects of non-steroidal anti-inflammatory (NSAIDs) mefenamic acid which is an anthranilic acid derivative. Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. Exploitation of the prodrug approach has the potential to achieve a reduction of mefenamic acid GI (gastrointestinal) intolerance, enhance its bioavailability, mask its unpleasant sensation and prolong its duration of action. Mefenamic acid, an effective NSAID has always been used as an anti-inflammatory and analgesic agent. A brief note on various marketed formulations of mefenamic acid provides an insight of the potential capability of this drug and its future scope.

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