Nano sponges: A targeted drug delivery system and its applications
DOI:
https://doi.org/10.30574/gscbps.2019.7.3.0098Keywords:
Nano sponges, Targeted dug delivery, Solubility enhancement, Controlled drug deliveryAbstract
The recent innovative advance in nanotechnology has led to the development of targeted drug delivery system. Targeting a molecule to a particular site with the help of a drug delivery system efficiently requires the use of specialized drug delivery systems. The invention of Nano sponges has become a significant step in overcoming the problems associated with conventional drug delivery systems. These are able to carry both hydrophilic and hydrophobic drugs. Nano sponge technology widely provide the controlled and predictable release of the drug to the targeted site. The Nano sponge particles circulate around the body and get attached with the target site and release the drug. A wide variety of drugs can be incorporated in the Nano sponge formulation since it possess a porous structure in nature. Nano sponge technology has been studied widely for the drug delivery by oral administration, topical administration and parenteral administration. Nano sponges can be used to prevent drug and protein degradation. Another important characteristic of Nano sponge is that they can improve the solubility of poorly water soluble drug. In this review advantages, composition, method of preparation, evaluation and application of different formulations of drugs and recent studies on Nano sponge have been discussed
Metrics
References
Bolmal VB, Manv FX, Rajkumar K, Palla SS, Paladugu A and Reddy KR. (2013). Recent advances in nanosponges as drug delivery systems. International Journal of Pharmaceutical Sciences and nanotechnology, 6(1), 1934-1944.
Aldawsari HM, Bader Eldwin, SM Labibgs and El- Kmel. (2015). Design and formulation of topical hydrogel integrating lemongrass loaded nanosphere with an enhanced antifungal effect in vitro / in vivo evaluation. International Journal of Nanomedicine, 10,893-902.
Jenny A, Merima P, Albert F, FracesioT. (2011). Role of β- cyclodextrin nanosponges in propylene photo oxidation. Carbohydrate Polymers, 86(1) 127-135.
Anuradha Salunkhe, Seemadei Kadam, Sayali Magar and Kiran Dangare. (2018) Nanosponges; a modern formulation approach drug delivery system. World Journal of Pharmacy and Pharmaceutical Sciences, 7(2), 575-592.
Suchita G. Waghmare, Rasika R. Nikhade, Dr. Satish and B. Kosalge. (2017). Nanosponges:a novel approach for controlled release drug delivery system. International Journal of Pharmacy and Pharmaceutical research, 9(3), 101-116.
Sharma R, Roderick B and Pathak K. (2011). Evaluation of kinetics and mechanism of drug release from econazole nitrate nanosponges loaded carbopol Hydrogel. Indian Journal of Pharmaceutical Education and Research, 45(1), 25-31.
Aritomi H, Yamasaki Y, Yamada K, Honda H and Khoshi M. (1996). Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. Journal of Pharmaceutical Science and Technology, 56(1), 49-52.
Kilicarslan M and Baykara T. (2003). The effect of the drug/polymer ratio on the properties of Verapamil HCl loaded microspheres. International Journal of Pharmaceutics, 252(1-2), 99–109.
Barkai A, Pathak V and Benita S. (1990). Polyacrylate microspheres for oral controlled release of nifedipine formulation, design and process optimization. Drug Development and Industrial Pharmacy, 16(13), 2057-2075.
Amber V, Shailendra S, Swarnalatha S. (2008). yclodextrin based novel drug delivery systems. Journal of Inclusion phenomena and macrocyclic chemistry, 62, 23-42.
Sinha VR, Anitha R, Ghosh S, Nanda A, Kumria R. (2005).Complexation of celecoxib with beta cyclodextrin: charecterization of the interaction in solution and in solid state. Journal of Pharmaceutical Sciences, 94(3), 676-687.
Lala R, Thorat A, and Gargote C. (2011). Current trends in beta- cyclodextrin based drug delivery systems. International Journal of Research in Ayurvedha and pharmacy, 2(5), 1520-1526.
Subramanian S, Singireddy A, Krishnamoorthy K, and Rajappan M. (2012). Nanosponges: a novel class of drug delivery system- review. Journal of Pharmacy and Pharmaceutical sciences, 15(1), 103- 111.
Swaminathan S, Pastero L, Serpe L, Trotta F, Vavia P, Aquilano D, Trotta M, Zara G and Cavalli R. (2010). Cyclodextrin –based nanosponges encapsulating camptothecin: Physiochemical characterization, stability and cytotoxicity. European Journal of Pharmaceutics and Biopharmaceutics, 74 (2), 193-201.
Ramnik S, Nitin B, Jyotsana M and Horemat SN. (2010). Charaecterization of cyclodextrin inclusion complexes- A Reveiw. Journal of Pharmaceutical Sciences and Technology, 2(3), 171-183.
Rajeswari C, Alka A, Javed A and Khar RK. (2005). Cyclodextrin in the drug delivery: an update review. American Association of Pharmaceutical Scientists, 6(2), E329-E357.
Selvamuthukumar S, Anandam S, Kannan K and Manavalan R. (2012). Nanosponge; A novel class of drug delivery system –review. Journal of Pharmacy and Pharmaceutical sciences, 15(1), 103-111.
Shastrulagari S and Samskruthi KP. (2015). Nanosponge: novel emerging drug delivery system- a review .International Journal of Pharmaceutical Sciences and Research,6(2), 1000-12.
Moura FC and Lago RM. (2009). Catalytic growth of carbon nanotubes and nanofibres on Vermiculite to produce floatable hydrophobic “Nanosponges” for oil spill remediation. Applied Catalysis B, 90(3-4, 436-40.
S. Eki, T. Lei, L Jingquan, J. Zhongfan, B. Cyrille, and P.D. Thomas. (2009). Biodegrdable star polymers functionalized with β-Cyclodextrin Inclusion Complexes. Bio macromolecule, 10(9), 2699-2707.
V.A. Davankov, M.M. Ilyin, M.P. Tsyurupu, G.I. Timofeeva and L.V. Dubrovina. (1996).From dissolved polystyrene coil to intramolecularly- hyper cross linked nanosponges. Macromolecule, 29(26), 8398-8403.
Swaminathan S, Trotta F and Tumbiolo S. (2013). Structural evidence of differential forms of nanosponges of beta –cyclodextrin. Journal of Inclusion Phenomena and Macrocyclic chemistry, 76(1-2), 201-211.
Cavali R, Akhter AK, Bisazza A, Giustetto P and Trotta F. (2010). Nanosponge Formulations as oxygen Delivery systems. International Journal of Pharmaceutics, 402(1-20), 254-7.
Moya –Ortega MD, Alvarez LC, Concherio A and Loftsson T. (2012). Cyclodextrin –based nanogels for pharmaceutical and biomedical applications. International Journal of Pharmaceutics, 428(1), 152-163.
JAnsari KA, Vavia PR, Trotta F and Cavalli R. (2011). Cyclodextrin –based nanosponges for delivery of resveratrol: in vitro charecterisation, stability, cytotoxicity and permeation study. AAPS PharmsciTech, 12(1), 279-286.
D.Lemboa, S Swaminathan and M. Donalisioa. (2013).Encapsulation of acyclovir in new carboxylated cyclodextrin based nanosponges improves the agent antiviral efficacy. International Journal of Pharmaceutics, 443(1-2), 262-272.
Mognetti B, Barberis A, Marino S and Trotta F. (2012). In vitro enhancement of anticancer activity of paclitaxel by a cremophor free cyclodextrin-based nanosponge formulations. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 74(1-4), 201-210.
Tejashri G, Amrita B and Darshana J. (2013). Cyclodextrin based nanosponges for pharmaceutical use; a review. Acta Pharma, 63(3), 335-358.
Boscolo B, Trotta F and Ghibaudi E. (2010). High catalytic performance of pseudomonas fluresecnce lipase desorbed on a new type of cyclodextrin based nanosponges. Journal of Molecular Catalysis B Enzymatic, 62, 155-161.
Swaminthan S, Cavalli R, Trotaa F and Fertti. (2010). In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of cyclodextrin. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 68(1-2), 183-191.
Rosalba M, Roberta C, Piergioorgio P, Roberto F, Leigh E and Chiara D. (2011). Antitumour activity of nanosponges –encapsulated camptotechin in human prostate tumours, 71(8), 4431-4431.
Guo L, Gao G, Liu X and Liu F. (2008). Preparation and charecterization of Tio2 nanosponges. Materials Chemistry and Physics, 111(2-3), 322-325.
Lee CL, Wu CC, Chiou HP, Syu CM, Huang CH and Yang CC. (2011). Mesoporous platinum nanosponges as electrocatalysts for the oxygen reduction reaction in an acidic electrolyte. International Journal of Hydrogen Energy, 36(11), 6433-6440.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
