Some studies on preparation and evaluation of microspheres containing homeopathic mother tincture of Nux-Vomica seeds

Milind Pande; Jibrin Hussaini; Keshri  Jha

doi:10.30574/gscbps.2019.8.2.0141

Authors

Milind Pande Professor & HOD, Department of Pharmacognosy, Teerthankar Mahaveer University, College of Pharmacy, Bagadpur, NH 24, Delhi Highway, Moradabad-244001 UP, India.
Jibrin Hussaini Jigawa State Ministries of Health, Dutse, Jigawa State, Nigeria.
Keshri Jha Principal, Teerthankar Mahaveer University, College of Pharmacy, Bagadpur, NH 24, Delhi Highway, Moradabad-244001 UP, India.

DOI:

https://doi.org/10.30574/gscbps.2019.8.2.0141

Keywords:

Strychnos nuxvomica, Nux-vomica, Peptic ulcer, Mother tincture, Sustained release dosage form

Abstract

The present study is aimed to investigate the effect of alcoholic mother tincture of Nux-vomica on Peptic ulcer patients with converting the tincture in microspheres. The seeds of Nux-vomica were purchased from local market and identified by University taxonomist Jaipur for authentication purpose. Using standard procedures as mentioned in text mother tincture was prepared and converted to dry powder form. This was further subjected to produce microspheres. Further the evaluations of microspheres were done by physico-chemical methods such as percentage yield, particle size analysis, bulk density, angle of repose and particle shape analysis. The results indicated that the ethanolic mother tincture of Strychnos nuxvomica Linn. Family Loganiaceae produced a significant and sustained quality of microspheres which can be used to enhance bioavailability and fast release to small and large intestine inner cell lining and will help in treatment of peptic ulcer, stomach ache and constipation in chronic cases.

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