Study on in vitro antioxidant activities of Chrysophyllum albidum G. Don stem-bark

Authors

  • Olufunke Christy Akanji Department of Plant Science and Biotechnology, Faculty of Science, Adekunle Ajasin University PMB 001, Akungba Akoko.Ondo State, Nigeria.

DOI:

https://doi.org/10.30574/gscbps.2020.11.1.0248

Keywords:

Chrysophyllum albidum, Folk medicine, Antioxidant, DPPH

Abstract

Chrysophyllum albidum G.Don is commonly known as African star apple. It possesses medicinal properties and used in folk medicine for the treatment of coronary heart diseases, stroke, anti-inflammatory, diabetes, cancers and diarrhea. Natural antioxidants either in the form of raw extracts or their chemical constituents are very effective to prevent the destructive processes caused by oxidative stress. The present study was carried out to investigate the phytochemicals and antioxidant activities of ethanol extract of Chrysophyllum albidum stem-bark. The phytochemical tests reviewed the presence of alkaloids (53%), tannins (6%), saponins (21%), flavonoids (10.25%), cardiac glycosides (21.36%), steroids (7.58%) and anthraquinone (8.72%). The overall antioxidant activities observed in the stem-bark of Chrysophyllum albidum showed strong free radical scavenging activity with DPPH (81.88±0.83 at 50 mg/ml) when compared with the reference chemical (TROLOX). The present study validates the traditional use, demonstrating that the stem-bark of Chrysophyllum albidum possesses concentration–dependent antioxidant activity.

Metrics

Metrics Loading ...

References

Idowu TO, Iwalewa EO, Aderogba MA, Akinpeluy BA and Ogunduini AO. (2006). Alkaloid Isolated from Chrysophyllum albidum Seed Cotyledons, Journal of Biological Sciences, 6(6), 1029-1034.

Devasagayam TPA, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS and Lele RD. (2004). Review: Free radicals and antioxidants in human health: Current Status and Full Prospects. J. Assoc Physicians India, 52, 794-804.

Deiana M, Arouma OI and Bianchi M. (1999). Inhibition of peroxinitite dependent DNA base modification and tyrocin nitration by the extra virgin olive oil derived antioxidant hydroxytyrosol. Free Radical Biology and Medicine, 26, 762-769.

Lee KG and Shibamoto T. (2000). Antioxidant properties of the Aroma compounds isolated from soyabean and mung beans. Journal of Agriculture and Food Chemistry, 48, 4290-4293.

Wang Z, Huang Y, Zou J, Cao K, Xu Y and Wu JM. (2002). Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro: International Journal of Molecular Medicine, 9(1), 77–79.

Kikuzaki H, Usuguchi J and Nakatani N. (1991). Constituents of Zingiberaceae I. Diarylheptanoid from the rhizomes of ginger (Zingiber officinale Roscoe). Chemistry and Pharmacy Bull, 39, 120.

Jitoe A, Masuda T and Tengah IGP. (1992). Antioxidant activity of tropical ginger extracts and analysis of the contained curcuminoids. Journal of Agricultural and Food Chemistry, 8, 1337.

Ethiagbonare, JE, Onyibe HI and Okoegwale EE. (2008). Studies on the isolation of normal and abnormal seedlings of Chrysophyllum albidum: A step towards sustainable management of the taxon in the 21st century: Science Research Essay, 3(12), 567-570.

Duyilemi OP and Lawal IO. (2009). Antibacterial activity and phytochemical screening of Chrysophyllum albidum Leaves: Asian Journal of Food and Agro-Industry. Special Issue, S75-79.

Amusa NA, Ashaye OA and Oladapo MO. (2003). Biodeterioration of the African star apple (Chrysophyllum albidum) in storage and the effect on its food value: African Journal of Biotechnology, 2(3), 56-59.

Adewusi HA. (1997). The African Star Apple Chrysophyllum albidum Indigenous Knowledge from Ibadan, Southwestern Nigeria: In Proceedings of a National Workshop on the Potentials of the Star Apple in Nigeria (Eds.), 25 – 33.

Bada SO. (1997). Preliminary information on the ecology of Chrysophyllum albidum done in the West and Central Africa: In proceedings of a National Workshop on the potentials of Star Apple in Nigeria, 16 – 25.

Marker AOS and Goodchild AV. (1996). Qualification of Tannis. A laboratory Manual International Centre of Agricultural Research in Dry Areas (ICRDA). Alleppo Syria, 4, 25.

Sofowora A. (2008). Medicinal Plants and Traditional Medicine in Africa’. 3rd edn. Spectrum Books, Ibadan, 64 – 79.

Gyamfi MA, Yonamine M. and Aaniya Y. (1999). Free radical scavenging action of medicinal herbs from Ghana: thonningia sanguine on experimentally induced liver injuries. General Pharmacology, 32, 661 – 667.

Bao JY, Cai M, Sun G, Wang M and Corke H. (2005). Anthocyanins, Flavonoid and Free Radical Scavenging Activity of thines Baybery (Myrialrubia) extracts and their colour properties and stability. Journal of Agriculture and Food Chemistry, 53, 2327 - 2332.

Re R, Pellegrin N, Proteggente A, Pannala A, Yang M and Rice-Evans C. (1999). Antioxidant activity applying an improve ABTS Radical cation decolourization assay. Free Radical Biology and Medicine, 26, 1231-1237.

Selvakumar K, Madhan R, Srinivasan G and Baskar V. (2011). Antioxidant Assays in Pharmacological Research. Asian Journal of Pharmaceutical Technology, 1(4), 99-103.

Halliwell B and Gutteridge JM. (1999). Formation of a thiobarbituric-acid-reactive substance from deoxyribose in the presence of iron salts: The role of superoxide and hydroxyl radicals FEBS. Letter, 128, 347-352.

Owolabi OJ, Omogbai E and Obasuyi O. (2007). Antifungal and antibacterial activities of the ethanolic and aqueous extracts of Kigelia africana (Bignoniaceae) stem bark. African Journal of Biotechnology, 6(14), 1677-1680.

Doughari JH, El-Mahmood AM and Tyoyina I. (2008). Antibacterial activity of leaf extracts of Senna obtusifolia. African Journal of Pharmaceutical Pharmacology, 2(1), 007-013.

Sofowora A. (1993). Medicinal Plants and Traditional Medicine in Africa 2nd Edn. Spectrum Books Limited, Ibadan, Nigeria, 14-34.

Umamaheswari M and Chatterjee TK. (2008). In vitro antioxidant activities of the fractions of Coccinnia grandis L. leaf extract. African Journal of Traditional Complementary and Alternative Medicine, 5, 61–73.

Kumpulainen JT and Salonen JT. (1999). Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease: The Royal Society of Chemistry, UK. 178- 187.

Downloads

Published

2020-04-30

How to Cite

Akanji , O. C. (2020). Study on in vitro antioxidant activities of Chrysophyllum albidum G. Don stem-bark. GSC Biological and Pharmaceutical Sciences, 11(1), 078–084. https://doi.org/10.30574/gscbps.2020.11.1.0248

Issue

Section

Original Article